Correlation analysis of STAT3 and VEGF expression and eosinophil infiltration in nasal polyps

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• 作者：Qingsong Cao ; Tao Zhang ; Jie Zhang
• 关键词：Nasal polyps ; Signal transducers and activators of transcription 3 ; Vascular endothelial growth factor ; Eosinophils
• 刊名：European Archives of Oto-Rhino-Laryngology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：272
• 期：8
• 页码：1955-1960
• 全文大小：783 KB
• 参考文献：1.Truman N, Nethercott D (2013) Posterior reversible encephalopathy syndrome (PRES). After treatment with oxaliplatin and 5-fluorouracil. Clin Colorectal Cancer 12:70-2. doi:10.-016/?j.?clcc.-012.-6.-03 PubMed View Article
  2.Bo G, Hui L, Feng-Li L, Cui L (2012) Relationships between edema degree and clinical and biochemical parameters in posterior reversible encephalopathy syndrome: a preliminary study. Acta Neurol Belg 112:281-85. doi:10.-007/?s13760-012-0060-y PubMed View Article
  3.K?mpe M, Stolt I, Lampinen M, Janson C, St?lenheim G, Carlson M (2011) Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge. Clin Mol Allergy 9:3. doi:10.-186/-476-7961-9-3 PubMed Central PubMed View Article
  4.Van Cauwenberge P, Van Hoecke H, Bachert C (2006) Pathogenesis of chronic rhinosinusitis. Curr Allergy Asthma Rep 6:487-94PubMed View Article
  5.Olsson S, Cagnoni F, Dignetti P, Melioli G, Canonica GW (2003) Low concentrations of cytokines produced by allergen-stimulated peripheral blood mononuclear cells have potent effects on nasal polyp-derived fibroblasts. Clin Exp Immunol 132:254-60PubMed Central PubMed View Article
  6.Groner B, Lucks P, Borghouts C (2008) The function of STAT3 in tumor cells and their microenvironment. Semin Cell Dev Biol 19:341-50. doi:10.-016/?j.?semcdb.-008.-6.-05 PubMed View Article
  7.Won C, Lee CS, Lee JK, Kim TJ, Lee KH, Yang YM, Kim YN, Ye SK, Chung MH (2010) CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation. Anticancer Res 30:481-88PubMed
  8.Kut C, Mac Gabhann F, Popel AS (2007) Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer. Br J Cancer 97:978-85PubMed Central PubMed View Article
  9.Lyer S, Acharya KR (2011) Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines. FEBS J 278:4304-322. doi:10.-111/?j.-742-4658.-011.-8350.?x View Article
  10.Wang JH, Kwon HJ, Jang YJ (2009) Rhinovirus upregulates matrix metalloproteinase-2, matrix metalloproteinase-9, and vascular endothelial growth factor expression in nasal polyp fibroblasts. Laryngoscope 119:1834-838. doi:10.-002/?lary.-0574 PubMed View Article
  11.Fokkens WJ, Lund VJ, Mullol J et al (2012) European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl (23):3 p preceding table of contents, 1-98
  12.Li F, Rajendran P, Sethi G (2010) Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br J Pharmacol 161:541-54. doi:10.-111/?j.-476-5381.-010.-0874.?x PubMed Central PubMed View Article
  13.Fleteher S, Turkson J, Gunning PT (2008) Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein. Chem Med Chen 3:1159-168. doi:10.-002/?cmdc.-00800123 View Article
  14.Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22:83-9. doi:10.-016/?j.?cytogfr.-011.-2.-03 PubMed View Article
  15.Sansone P, Bromberg J (2012) Targeting the interleukin-6/Jak/stat pathing in human malignancies. J Clin Oncol 30:1005-014. doi:10.-200/?JCO.-010.-1.-907.?Epub PubMed Central PubMed View Article
  16.Bates ME, Sedgwick JB, Zhu Y, Liu LY, Heuser RG, Jarjour NN, Kita H (2010) Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils. J Immunol 184:7125-133. doi:10.-049/?jimmunol.-900634 PubMed Central PubMed View Article
  17.Matsumoto K, Fukuda S, Hashimoto N, Saito H (2011) Human eosinophils produce and release a novel chemokine, CCL23, in vitro. Int Arch Allergy Immunol 155:34-9. doi:10.-159/-00327263 PubMed View Article
  18.Tammela T, Zarkada G, Wallgard E et al (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454:656-60. doi:10.-038/?nature07083 PubMed View Article
  19.Lee HS, Myers A, Kim J (2009) Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis. Am J Respir Crit Care Med 180:1056-067. doi:10.-164/?rccm.-00905-0740OC PubMed Central PubMed View Article
  20.You Z, Xu D, Ji J, Guo W, Zhu W, He J (2012) JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma. Clin Transl Oncol 14:143-49. doi:10.-007/?s12094-012-0774-6 PubMed View Article
  21.Slattery ML, Lundgreen A, Kadlubar SA, Bondurant KL, Wolff RK (2011) JAK/STAT/SOCS-signaling pathway and colo
• 作者单位：Qingsong Cao (1)
  Tao Zhang (1)
  Jie Zhang (2)
  
  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China
  2. VIP Ward, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Otorhinolaryngology
  Neurosurgery
  Head and Neck Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1434-4726

文摘

The expression and distribution of signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), and vascular endothelial growth factor (VEGF), as well as eosinophil infiltration in nasal polyps was detected to examine their roles and correlations in the nasal polyp pathogenesis. Using the streptavidin-biotin-peroxidase (SP) method, immunohistochemistry was performed on conventional paraffin sections of 30 surgery-resected polypous specimens and 10 inferior turbinate tissues that were resected during nasal septum deflection correction to detect the expression of STAT3, p-STAT3, and VEGF, as well as eosinophil infiltration. The rates of STAT3-, p-STAT3-, and VEGF-positive expression in the mucosal epithelium and glands of nasal polyps were 66.67, 56.67, and 76.67?%, respectively, values that were significantly higher than those in the inferior turbinate group. The number of eosinophils in the nasal polyps was significantly higher than in the inferior turbinate group. Expression of p-STAT3 and VEGF in nasal polyps and eosinophil infiltration was increased significantly and positively correlated, indicating that VEGF and eosinophil infiltration might be regulated by p-STAT3. Therefore, the expression of STAT3, p-STAT3, and VEGF, and eosinophil infiltration might be important factors in nasal polyp pathogenesis.