Awareness is essential for differential delay eyeblink conditioning with soft-tone but not loud-tone conditioned stimuli

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• 作者：He Huang (1) (2)
  Bing Wu (2)
  Qiong Li (2)
  Juan Yao (2)
  Xuan Li (2)
  Yi Yang (2)
  Guang-Yan Wu (1) (2)
  Jian-Feng Sui (1) (2)
  
• 关键词：awareness ; differential delay eyeblink conditioning ; soft ; tone conditioned stimulus ; loudtone conditioned stimulus
• 刊名：Neuroscience Bulletin
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：30
• 期：3
• 页码：433-440
• 全文大小：
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• 作者单位：He Huang (1) (2)
  Bing Wu (2)
  Qiong Li (2)
  Juan Yao (2)
  Xuan Li (2)
  Yi Yang (2)
  Guang-Yan Wu (1) (2)
  Jian-Feng Sui (1) (2)
  
  1. Department of Physiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China
  2. Experimental Center of Basic Medicine, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China
  
• ISSN：1995-8218

文摘

The role of awareness in differential delay eyeblink conditioning (DEC) remains controversial. Here, we investigated the involvement of awareness in differential DEC with a soft or a loud tone as the conditioned stimulus (CS). In the experiment, 36 participants were trained in differential DEC with a soft tone (60 dB) or a loud tone (85 dB) as the CS, paired with a corneal air-puff as the unconditioned stimulus (US). After conditioning, awareness of the relationship between the CS and the US was assessed with a 17-item true/false questionnaire. Interestingly, during differential DEC with a soft-tone CS, a higher proportion of differential conditioned responses (CRs) was evident in participants who were aware than those who were unaware. In contrast, when a loud tone was used as the CS, the proportion of differential CRs of the aware participants did not differ significantly from those who were unaware over any of the blocks of 20 trials. In unaware participants, the percentage of differential CRs with a loud-tone CS was significantly higher than that with a soft-tone CS; however in participants classified as aware, the percentage of differential CRs with a loud-tone CS did not differ significantly from that with a soft-tone CS. The present findings suggest that awareness is critical for differential DEC when the delay task is rendered more difficult.