Epigenetics of Notch1 regulation in pulmonary microvascular rarefaction following extrauterine growth restriction
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- 作者：Li-Li Tang ; Li-Yan Zhang ; Lin-Jiang Lao ; Qiong-Yao Hu ; Wei-Zhong Gu…
- 关键词：Extrauterine growth restriction ; Pulmonary endothelium ; Notch1 ; Epigenetics
- 刊名：Respiratory Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：2,367 KB
- 刊物主题：Pneumology/Respiratory System;
- 出版者：BioMed Central
- ISSN：1465-9921
文摘
Background Extrauterine growth restriction (EUGR) plays an important role in the developmental origin of adult cardiovascular diseases. In an EUGR rat model, we reported an elevated pulmonary arterial pressure in adults and genome-wide epigenetic modifications in pulmonary vascular endothelial cells (PVECs). However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular consequences later in life remains unclear.