Lanthanum chloride impairs spatial learning and memory and downregulates NF-κB signalling pathway in rats

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• 作者：Linlin Zheng (1) (2) (3)
  Jinghua Yang (1) (3)
  Qiufang Liu (1) (3)
  Fei Yu (1) (4)
  Shengwen Wu (1) (3)
  Cuihong Jin (1) (3)
  Xiaobo Lu (1) (3)
  Lifeng Zhang (1) (3) (5)
  Yanqiu Du (1) (3) (6)
  Qi Xi (7)
  Yuan Cai (1) (3)
  
• 关键词：Lanthanum ; Learning ; Memory ; Hippocampus ; NF ; κB
• 刊名：Archives of Toxicology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：87
• 期：12
• 页码：2105-2117
• 全文大小：
• 作者单位：Linlin Zheng (1) (2) (3)
  Jinghua Yang (1) (3)
  Qiufang Liu (1) (3)
  Fei Yu (1) (4)
  Shengwen Wu (1) (3)
  Cuihong Jin (1) (3)
  Xiaobo Lu (1) (3)
  Lifeng Zhang (1) (3) (5)
  Yanqiu Du (1) (3) (6)
  Qi Xi (7)
  Yuan Cai (1) (3)
  
  1. Department of Toxicology, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, Liaoning, People’s Republic of China
  2. School of Medicine, Eastern Liaoning University, 49 Jingshan Street, Zhenan District, Dandong, 118000, Liaoning, People’s Republic of China
  3. Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, Liaoning, People’s Republic of China
  4. Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning, People’s Republic of China
  5. Heping District Center for Disease Control and Prevention, Shenyang, Liaoning, People’s Republic of China
  6. Shenyang Ninth People’s Hospital, Shenyang, Liaoning, People’s Republic of China
  7. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
  
• ISSN：1432-0738

文摘

Exposure to rare earth elements (REEs) is known to impair intelligence in children and cause neurobehavioral abnormalities in animals. However, the mechanisms underlying these phenomena are not clear. Lanthanum is often used to study the effects of REEs. The aim of this study was to investigate the influence of lanthanum chloride (LaCl3) on spatial learning and memory and a possible underlying mechanism involving nuclear factor-kappa B (NF-κB) signalling pathway expression in the hippocampus. The rats were exposed to 0, 0.25, 0.50 or 1.00?% LaCl3 in drinking water during pregnancy and lactation (i.e. while feeding their offspring). After weaning, young rats continued to receive 0, 0.25, 0.50 and 1.00?% LaCl3 in the drinking water for 1?month. LaCl3 exposure impaired the spatial learning and memory of young rats and significantly decreased the expression of phosphorylated IκB kinase complex, phosphorylated IκBα, NF-κB, c-fos, c-jun and brain-derived neurotrophic factor in the hippocampus. These results indicate that LaCl3 exposure impairs spatial learning and memory in rats by inhibiting NF-κB signalling pathway.