Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells

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• 作者：Jie Wu ; Ming Cheng ; Qiufang Liu ; Jinghua Yang…
• 关键词：Sodium fluoride ; Apoptosis ; Nuclear factor ; erythroid 2 ; related factor 2 ; tert ; Butylhydroquinone
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：35
• 期：7
• 页码：1017-1025
• 全文大小：1,768 KB
• 参考文献：Akhter H, Katre A, Li L, Liu X, Liu RM (2011) Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer’s disease. J Alzheimer’s Dis 26:767-78
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• 作者单位：Jie Wu (1) (2)
  Ming Cheng (1)
  Qiufang Liu (1)
  Jinghua Yang (1)
  Shengwen Wu (1)
  Xiaobo Lu (1)
  Cuihong Jin (1)
  Honglin Ma (2)
  Yuan Cai (1)
  
  1. Department of Toxicology, School of Public Health, China Medical University, Shenyang, 110013, Liaoning, China
  2. Department of Occupational and Environmental Health, School of Public Health, Liaoning Medical University, Jinzhou, 121001, Liaoning, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830

文摘

The neurotoxicity of fluoride is associated with oxidative stress due to imbalance between production and removal of reactive oxygen species (ROS). In contrast, induction of detoxifying and antioxidant genes through activation of NF-E2-related factor 2 (Nrf2) has been implicated in preventing oxidative stress and apoptosis in neurodegenerative diseases. The present study aimed to investigate the possible neuroprotective role of tert-butylhydroquinone (tBHQ), a general Nrf2 activator, on sodium fluoride (NaF)-induced oxidation damage and apoptosis in neuron-like rat pheochromocytoma (PC12) cells. Pretreatment with tBHQ protected PC12 cells against NaF-induced cytotoxicity as measured by MTT assay and apoptosis detection, simultaneously, inhibited NaF-induced overproduction of intracellular ROS and reduction of total glutathione content. Furthermore, NaF or tBHQ induced the stabilization of Nrf2, and enhanced expression of heme oxygenase-1 (HO-1) and γ-glutamylcysteine synthetase (γ-GCS) as a consequence of Nrf2 inducing. These findings indicated that tBHQ pretreatment conferred protective effect on PC12 cells against NaF-induced apoptotic cell death and oxidation-redox imbalance through stabilization of Nrf2 and elevation of downstream HO-1 and γ-GCS expressions. Keywords Sodium fluoride Apoptosis Nuclear factor-erythroid 2-related factor 2 tert-Butylhydroquinone