Lanthanum Chloride Impairs Spatial Memory Through ERK/MSK1 Signaling Pathway of Hippocampus in Rats
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- 作者：Huiying Liu (1) (2)
Jinghua Yang (1) (2)
Qiufang Liu (1) (2)
Cuihong Jin (1) (2)
Shengwen Wu (1) (2)
Xiaobo Lu (1) (2)
Linlin Zheng (3)
Qi Xi (4)
Yuan Cai (1) (2) - 关键词：Lanthanum chloride ; Spatial learning and memory ; Synaptic ; ERK/MSK1 ; Hippocampus
- 刊名：Neurochemical Research
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：39
- 期：12
- 页码：2479-2491
- 全文大小：2,304 KB
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20. Zheng L, Yang J, Liu Q et al (2013) Lanthanum chloride impairs spatial learning and memory and downregulates NF-kappaB signalling pathway in rats. - 作者单位：Huiying Liu (1) (2)
Jinghua Yang (1) (2)
Qiufang Liu (1) (2)
Cuihong Jin (1) (2)
Shengwen Wu (1) (2)
Xiaobo Lu (1) (2)
Linlin Zheng (3)
Qi Xi (4)
Yuan Cai (1) (2)
1. Department of Toxicology, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, Liaoning, People’s Republic of China
2. Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, Liaoning, People’s Republic of China
3. School of Medicine, Eastern Liaoning University, 49 Jingshan Street, Zhenan District, Dandong, Liaoning, People’s Republic of China
4. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA - ISSN：1573-6903
文摘
Rare earth elements (REEs) are used in many fields for their diverse physical and chemical properties. Surveys have shown that REEs can impair learning and memory in children and cause neurobehavioral defects in animals. However, the mechanism underlying these impairments has not yet been completely elucidated. Lanthanum (La) is often selected to study the effects of REEs. The aim of this study was to investigate the spatial memory impairments induced by lanthanum chloride (LaCl3) and the probable underlying mechanism. Wistar rats were exposed to LaCl3 in drinking water at 0?% (control, 0?mM), 0.25?% (18?mM), 0.50?% (36?mM), and 1.00?% (72?mM) from birth to 2?months after weaning. LaCl3 considerably impaired the spatial learning and memory of rats in the Morris water maze test, damaged the synaptic ultrastructure and downregulated the expression of p-MEK1/2, p-ERK1/2, p-MSK1, p-CREB, c-FOS and BDNF in the hippocampus. These results indicate that LaCl3 exposure impairs the spatial learning and memory of rats, which may be attributed to disruption of the synaptic ultrastructure and inhibition of the ERK/MSK1 signaling pathway in the hippocampus.