Morphogenesis of T-tubules in heart cells: the role of junctophilin-2
详细信息 查看全文
- 作者：Jing Han (14490)
HaoDi Wu (14490)
QiWei Wang (14490)
ShiQiang Wang (14490) - 关键词：T ; tubules ; junctophilin ; 2 ; cardiomyocytes ; morphogenesis
- 刊名：Science China Life Sciences
- 出版年：2013
- 出版时间：July 2013
- 年：2013
- 卷：56
- 期：7
- 页码：647-652
- 全文大小：663KB
- 参考文献：1. Bers D M. Excitation-contraction Coupling and Cardiac Contractile Force. 2nd ed. Dordrecht (the Netherlands): Kluwer Academic Publisher, 2001 CrossRef
2. Forbes M S, Hawkey L A, Sperelakis N. The transverse-axial tubular system (TATS) of mouse myocardium: its morphology in the developing and adult animal. Am J Anat, 1984, 170: 143-62 CrossRef
3. Brette F, Orchard C. T-tubule function in mammalian cardiac myocytes. Circ Res, 2003, 92: 1182-192 CrossRef
4. Soeller C, Cannell M B. Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circ Res, 1999, 84: 266-75 CrossRef
5. Cartwright E J, Oceandy D, Austin C, et al. Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps. Sci China Life Sci, 2011, 54: 691-98 CrossRef
6. Cheng H, Cannell M B, Lederer W J. Propagation of excitation-contraction coupling into ventricular myocytes. Pflugers Arch, 1994, 428: 415-17 CrossRef
7. Song L S, Guatimosim S, Gomez-Viquez L, et al. Calcium biology of the transverse tubules in heart. Ann New York Acad Sci, 2005, 1047: 99-11 CrossRef
8. Franzini-Armstrong C, Protasi F. Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol Rev, 1997, 77: 699-29
9. Franzini-Armstrong C, Protasi F, Ramesh V. Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles. Biophys J, 1999, 77: 1528-539 CrossRef
10. Kimlicka L, Van Petegem F. The structural biology of ryanodine receptors. Sci China Life Sci, 2011, 54: 712-24 CrossRef
11. Lopez-Lopez J R, Shacklock P S, Balke C W, et al. Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science, 1995, 268: 1042-045 CrossRef
12. Berridge M J, Bootman M D, Roderick H L. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev, 2003, 4: 517-29 CrossRef
13. Bers D M. Cardiac excitation-contraction coupling. Nature, 2002, 415: 198-05 CrossRef
14. Di Maio A, Karko K, Snopko R M, et al. T-tubule formation in cardiomyocytes: two possible mechanisms? J Muscle Res Cell Motil, 2007, 28: 231-41 CrossRef
15. Takeshima H, Komazaki S, Nishi M, et al. Junctophilins: a novel family of junctional membrane complex proteins. Mol Cell, 2000, 6: 11-2
16. Escobar A L, Ribeiro-Costa R, Villalba-Galea C, et al. Developmental changes of intracellular Ca2+ transients in beating rat hearts. Am J Physiol, 2004, 286: H971–H978 CrossRef
17. Snopko R M, Ramos-Franco J, Di Maio A, et al. Ca2+ sparks and cellular distribution of ryanodine receptors in developing cardiomyocytes from rat. J Mol Cell Cardiol, 2008, 44: 1032-044 CrossRef
18. Nishi M, Mizushima A, Nakagawara K, et al. Characterization of human junctophilin subtype genes. Biochem Biophys Res Commun, 2000, 273: 920-27 CrossRef
19. Garbino A, Wehrens X H. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin, 2010, 31: 1019-021 CrossRef
20. Hirata Y, Brotto M, Weisleder N, et al. Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes. Biophys J, 2006, 90: 4418-427 CrossRef
21. Landstrom A P, Kellen C A, Dixit S S, et al. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circulation, 2011, 4: 214-23
22. van Oort R J, Garbino A, Wang W, et al. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation, 2011, 123: 979-88 CrossRef
23. Wei S, Guo A, Chen B, et al. T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res, 2010, 107: 520-31 CrossRef
24. Wu H D, Xu M, Li R C, et al. Ultrastructural remodelling of Ca(2+) signalling apparatus in failing heart cells. Cardiovas Res, 2012, 95: 430-38 CrossRef
25. Fu Y, Zhang G Q, Hao X M, et al. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes. Biophys J, 2005, 89: 2533-541 CrossRef
26. Song L S, Sobie E A, McCulle S, et al. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci USA, 2006, 103: 4305-310 CrossRef
27. Liang X, Mei Y, Huang X, et al. Junctophilin 2 knockdown interfere with mitochondrium status in ESC-CMs and cardiogenesis of ES cells. J Cell Biochem, 2012, 113: 2884-894 CrossRef
28. Perez C G, Copello J A, Li Y, et al. Ryanodine receptor function in newborn rat heart. Am J Physiol, 2005, 288: H2527–H2540 - 作者单位：Jing Han (14490)
HaoDi Wu (14490)
QiWei Wang (14490)
ShiQiang Wang (14490)
14490. State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China
文摘
The T-tubule (TT) system forms the structural basis for excitation-contraction coupling in heart and muscle cells. The morphogenesis of the TT system is a key step in the maturation of heart cells because it does not exist in neonatal cardiomyocytes. In the present study, we quantified the morphological changes in TTs during heart cell maturation and investigated the role of junctophilin-2 (JP2), a protein known to anchor the sarcoplasmic reticulum (SR) to TT, in changes to TT morphological parameters. Analysis of confocal images showed that the transverse elements of TTs increased, while longitudinal elements decreased during the maturation of TTs. Fourier transform analysis showed that the power of ? μm spatial components increased with cardiomyocytes maturation. These changes were preceded by increased expression of JP2, and were reversed by JP2 knockdown. These findings indicate that JP2 is required for the morphogenesis of TTs during heart development.