Transcriptional profiles in bursal B-lymphoid DT40 cells infected with very virulent infectious bursal disease virus
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- 作者：Rong Quan ; Shanshan Zhu ; Li Wei ; Jing Wang ; Xu Yan ; Zixuan Li ; Jue Liu
- 关键词：vvIBDV ; Microarray ; DT40 cells ; Pathway analysis ; Toll ; like receptors ; Inflammatory response ; Bursa
- 刊名：Virology Journal
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：14
- 期：1
- 全文大小：964KB
- 刊物主题：Virology;
- 出版者：BioMed Central
- ISSN：1743-422X
- 卷排序：14
文摘
BackgroundInfectious bursal disease virus (IBDV) causes a highly contagious, immunosuppressive disease in chickens. The virus mainly infects immature B lymphocytes in the bursa of Fabricius (BF). Chicken B cell line DT40, an avian leukosis virus-induced B cell line, supports very virulent IBDV (vvIBDV) infection in vitro and thereby serves as a good model for investigating the infection and pathogenesis of this virus. However, a transcriptome-wide understanding of the interaction between vvIBDV and B cells has not yet been achieved. This study aimed to employ time-course DNA microarrays to investigate gene expression patterns in DT40 cells after infection with vvIBDV strain LX.