Access to antimycobacterial and anticancer potential of some fused quinazolines

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• 作者：Amit B. Patel ; Kishor H. Chikhalia ; Premlata Kumari
• 关键词：Quinazoline ; Benzothiazole ; Suzuki coupling ; Anticancer ; Antimycobacterial activity
• 刊名：Research on Chemical Intermediates
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：41
• 期：7
• 页码：4439-4455
• 全文大小：439 KB
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• 作者单位：Amit B. Patel (1)
  Kishor H. Chikhalia (2)
  Premlata Kumari (1)
  
  1. Department of Applied Chemistry, S. V. National Institute of Technology, Surat, 395007, India
  2. Department of Chemistry, School of Science, Gujarat University, Ahmedabad, 380 009, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1568-5675

文摘

Two series of some various N-phenyl/benzothiazolyl acetamide-fused quinazoline derivatives were synthesized and tested for their antimycobacterial activity against M. tuberculosis H37Rv. Moreover, the synthesized analogs were also screened against human PC3 cells in order to explore their anticancer activity. The in vitro antimycobacterial screening revealed that, among the synthesized analogs, N-benzothiazolyl acetamide derivatives showed remarkable antimycobacterial activity. However, the best anticancer results were observed amongst the N-phenyl acetamide-substituted quinazoline derivatives. The newly synthesized compounds were characterized through IR, 1H NMR, 13C NMR, MS, and elemental analysis.