Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes

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• 作者：Wei Zheng ; Yao Zhao ; Qun Luo ; Yang Zhang ; Kui Wu ; Fuyi Wang
• 关键词：anticancer agents ; metal complexes ; multi ; targeting ; EGFR ; inhibition ; DNA binding
• 刊名：SCIENCE CHINA Chemistry
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：59
• 期：10
• 页码：1240-1249
• 全文大小：1,754 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Chinese Library of Science
  Chemistry
  
• 出版者：Science China Press, co-published with Springer
• ISSN：1869-1870
• 卷排序：59

文摘

Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.