Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)

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• 作者：Xu Zhang (1)
  Juan Li (1)
  MinJie Chen (1)
  Le Wu (2)
  Chi Zhang (2)
  Jie Zhang (1)
  QunFang Zhou (3)
  Yong Liang (2) (3)
  
• 关键词：brominated flame retardants (BFRs) ; tris ; (2 ; 3 ; dibromopropyl) isocyanurate (TBC) ; zebrafish ; endocrine disrupting effect ; vitellogenin
• 刊名：Chinese Science Bulletin
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：56
• 期：15
• 页码：1548-1555
• 全文大小：1541KB
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• 作者单位：Xu Zhang (1)
  Juan Li (1)
  MinJie Chen (1)
  Le Wu (2)
  Chi Zhang (2)
  Jie Zhang (1)
  QunFang Zhou (3)
  Yong Liang (2) (3)
  
  1. Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China
  2. School of Medicine, Jianghan University, Wuhan, 430056, China
  3. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China
  
• ISSN：1861-9541

文摘

Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China. TBC is semi-volatile and can accumulate in the lipid of some species, but little is known about its effect on aquatic organisms. We exposed adult zebrafish to 0, 0.25, 1 and 4 mg/L TBC for 28 d and measured the effect on survival, growth, histopathology, hormone levels, enzyme activity, and gene expression. TBC exposure had no effect on survival or growth. We observed significant damage to the liver and gill, including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills. In addition, exposure to 4 mg/L TBC induced proliferation of goblet cells in the intestine of both sexes, acellular areas in the testis, and thinly scattered vitellogenic granules in vitellogenic oocytes. TBC exposure had no effect on the levels of thyroid hormones, testosterone, estradiol, liver superoxide dismutase activity, malondialdehyde content, and brain cholinesterase activity. By contrast, hepatic vitellogenin and cytochrome P4501A gene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure. Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects.