Estimation of Intra-vitreal Half-Lifes in the Rabbit Eye with Semi-mechanistic Equations

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• 作者：Walter Schmitt
• 关键词：KEY WORDShalf ; life ; intravitreal ; ocular ; ocular pharmacokinetics ; rabbit eye
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：49-57
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeTo develop an alternative method for estimating vitreal half-lifes in the rabbit eye based on simple equations for the physical processes of dissipation and the physiochemical properties of therapeutic substances applied by intravitreal drug administration.