Prevalence of vitamin D deficiency rickets in the eastern part of Turkey

详细信息    查看全文

• 作者：Behzat Ozkan (1) (6)
  Hakan Doneray (1)
  Mehmet Karacan (2)
  Serhat Van?elik (3)
  Zuhal Keskin Y?ld?r?m (2)
  Asuman Ozkan (4)
  Celalettin Kosan (2)
  Kamil Ayd?n (5)
  
• 关键词：Prevalence ; Rickets ; Children
• 刊名：European Journal of Pediatrics
• 出版年：2009
• 出版时间：January 2009
• 年：2009
• 卷：168
• 期：1
• 页码：95-100
• 全文大小：116KB
• 参考文献：1. Akpede GO, Omotara BA, Ambe JP (1999) Rickets and deprivation: a Nigerian study. J R Soc Health 119:216-22 ss="external" href="http://dx.doi.org/10.1177/146642409911900403">CrossRef
  2. Alag?l F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, Sandalci O (2000) Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 23:173-77
  3. Andiran N, Yordam N, Oz?n A (2002) Risk factors for vitamin D deficiency in breast-fed newborns and their mothers. Nutrition 18:47-0 ss="external" href="http://dx.doi.org/10.1016/S0899-9007(01)00724-9">CrossRef
  4. Baroncelli GI, Bereket A, El Kholy M, Audì L, Cesur Y, Ozkan B, Rashad M, Fernández-Cancio M, Weisman Y, Saggese G, Hochberg Z (2008) Rickets in the Middle East: role of environment and genetic predisposition. J Clin Endocrin Metab 93:1743-750 ss="external" href="http://dx.doi.org/10.1210/jc.2007-1413">CrossRef
  5. Bereket A (2003) Rickets in developing countries. In: Hocberg Z (ed) Endocrine development. Vitamin D and rickets. Karger, pp 20-2
  6. Glowacki J (2007) Vitamin D inadequacy in 2007: what it is and how to manage it. Curr Opin Orthop 18:480-85 ss="external" href="http://dx.doi.org/10.1097/BCO.0b013e3282ab992f">CrossRef
  7. Gordon CM, Feldman HA, Sinclair L, Williams AL, Kleinman PK, Perez-Rossello J, Cox JE (2008) Prevalence of vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolesc Med 162:505-12 ss="external" href="http://dx.doi.org/10.1001/archpedi.162.6.505">CrossRef
  8. Gültekin A, Sava? A, ?zalp ? (1985) 0- ya? grubunda ra?itizmin g?rülme s?kl???. ?ocuk Sa?l??? ve Hastal?klar? Dergisi 28:119-25
  9. Hatun S, Ozkan B, Orbak Z, Doneray H, Cizmecioglu F, Toprak D, Calyko?lu AS (2005) Vitamin D deficiency in early infancy. J Nutr 135:279-82
  10. Hatun S, Bereket A, Ozkan B, Co?kun T, K?se R, Calyko?lu AS (2007) Free vitamin D supplementation for every infant in Turkey. Arch Dis Child 92:373-74 ss="external" href="http://dx.doi.org/10.1136/adc.2006.113829">CrossRef
  11. Holick MF (2006) Resurrection of vitamin D deficiency and rickets. J Clin Invest 116:2062-072 ss="external" href="http://dx.doi.org/10.1172/JCI29449">CrossRef
  12. Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S-086S
  13. Jalal OM, El Nabawy M, Hassan A, Hassan A (1970) Incidence of rickets in two children populations in Egypt. Aimn Shams Med J 21:133-37
  14. Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF (2007) Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr 46:42-4 ss="external" href="http://dx.doi.org/10.1177/0009922806289311">CrossRef
  15. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M; Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society (2008) Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 122:398-17 ss="external" href="http://dx.doi.org/10.1542/peds.2007-1894">CrossRef
  16. Muhe L, Lulseged S, Mason KE, Simoes EAF (1997) Case–control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 349:1801-804 ss="external" href="http://dx.doi.org/10.1016/S0140-6736(96)12098-5">CrossRef
  17. Nagi NA (1972) Vitamin D deficiency rickets in malnourished children. J Trop Med Hyg 75:251-54
  18. Nicholson JF, Pesce MA (2004) Reference ranges for laboratory tests and procedures. In: Behrman RE, Kliegman RM, Jenson HB (eds) Nelson textbook of pediatrics, 17th edn. Saunders, pp 2396-426
  19. Orhan F (2006) Clinical characteristics of vitamin D deficiency rickets in infants aged 0- months. Thesis, Erzurum, Turkey
  20. Ozkan B, Büyükavc? M, Aksoy H, Tan H, Akda? R (1999) Incidence of rickets among 0- year old children in Erzurum. Cocuk Sa?li?i ve Hastaliklari Dergisi 42:389-96
  21. Parent MA, Khadraoui S, de Schampheleire I (1987) Early clinical rickets and its association with malnutrition. J Trop Pediatr 1:13-5
  22. Pehlivan I, Hatun S, Aydogan M, Babaoglu K, Turker G, G?kalp AS (2002) Maternal serum vitamin D levels in the third trimester of pregnancy. Turk J Med Sci 32:237-41
  23. Pettifor JM (1994) Privational rickets: a modern perspective. J R Soc Med 87:723-25
  24. Pettifor JM (2000) What is the optimal 25 (OH) D level for bone in children? In: Norman AW, Bouillon R, Thomasset M (eds) Vitamin D endocrine system: structural, biological, genetic and clinical aspects. University of California, pp 903-07
  25. Thacher TD, Fischer PR, Strand MA, Pettifor JM (2006) Nutritional rickets around the world: causes and future directions. Ann Trop Paediatr 26:1-6 ss="external" href="http://dx.doi.org/10.1179/146532806X90556">CrossRef
  26. The annual statistics book of health: Erzurum in Turkey (2006) Health Directorate of Erzurum Province, p 11
  27. Underwood P, Margetts B (1987) High levels of childhood rickets in rural North Yemen. Soc Sci Med 24:37-1 ss="external" href="http://dx.doi.org/10.1016/0277-9536(87)90136-5">CrossRef
  28. Wharton B, Bishop N (2003) Rickets. Lancet 362:1389-400 ss="external" href="http://dx.doi.org/10.1016/S0140-6736(03)14636-3">CrossRef
  
• 作者单位：Behzat Ozkan (1) (6)
  Hakan Doneray (1)
  Mehmet Karacan (2)
  Serhat Van?elik (3)
  Zuhal Keskin Y?ld?r?m (2)
  Asuman Ozkan (4)
  Celalettin Kosan (2)
  Kamil Ayd?n (5)
  
  1. Department of Pediatric Endocrinology, Ataturk University, Erzurum, Turkey
  6. Atatürk üniversitesi T?p Fakültesi Pediatrik Endokrinoloji BD, Erzurum, Türkiye
  2. Department of Pediatrics, Ataturk University, Erzurum, Turkey
  3. Department of Public Health, Ataturk University, Erzurum, Turkey
  4. Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey
  5. Faculty of Humanities, Ataturk University, Erzurum, Turkey
  

文摘

Turkey, especially its eastern part, has been accepted as endemic for vitamin D deficiency rickets (VDDR). In a study performed by our team in the region in 1998, the incidence of VDDR was 6.09% in children aged between 0- years. In 2005, the Ministry of Health initiated a free vitamin D supplementation campaign nationwide for every infant to eradicate VDDR. In this study, we aimed to investigate the prevalence of VDDR in children aged between 0- years in order to evaluate the effectiveness of this campaign. Between March 2007 and February 2008, 39,133 children aged between 0- years who were brought to different pediatric outpatient clinics in Erzurum, Turkey, were examined for VDDR. VDDR diagnosis was made by radiological and biochemical findings in the cases who were initially suspected of having clinical VDDR. During a one-year period, 39 (0.099%) of the 39,133 patients were diagnosed with VDDR. None of the cases with rickets was taking vitamin D supplementation. The most frequent physical findings were rachitic rosary, enlargement of the wrists, and craniotabes. The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5?±-.9?mg/dL, PO4sub> 4.4?±-.3?mg/dL, alkaline phosphatase (ALP) 1,341?±-23, 25-hydroxyvitamin D (25 (OH) D) 5.8?±-.9?ng/mL, intact parathyroid hormone (iPTH) 240?±-06?pg/mL. It was concluded that, although VDDR has been a continuing childhood health problem, a nationwide free vitamin D supplementation campaign initiated by the government appeared to be effective in eliminating VDDR.