Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy
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- 作者：Lihong Chang ; Jiancong Huang ; Kai Wang ; Jingjia Li ; Ruicheng Yan ; Ling Zhu…
- 关键词：Nasopharyngeal carcinoma ; Radiosensitization ; MRN complex ; Rad50
- 刊名：BMC Cancer
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：16
- 期：1
- 全文大小：1,665 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background The Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting native cellular MRN function would sensitize NPC cells to IR.