Protection of radiation induced DNA damage by a newly developed molybdenum complex

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• 作者：Md. Selim ; Abhijit Saha ; Kalyan K. Mukherjea
• 关键词：Gamma radiation ; DNA damage ; DNA protection ; Glutathione ; Molybdenum glutathione
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：311
• 期：1
• 页码：189-193
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nuclear Chemistry; Physical Chemistry; Nuclear Physics, Heavy Ions, Hadrons; Diagnostic Radiology; Inorganic Chemistry;
• 出版者：Springer Netherlands
• ISSN：1588-2780
• 卷排序：311

文摘

Ionizing radiation, especially gamma (γ) radiation, is assumed to be very effective for DNA damage due to formation of free radicals. DNA damage and inhibition of DNA damage produced on irradiation with 60Co gamma source were characterized by fluorescence spectrometry. Reduced form of glutathione (GSH) and its novel molybdenum glutathione (MoG) complex were employed for the protection of γ-radiation induced DNA damage. The spectroscopic results of the present study showed that the MoG complex is more efficient in protecting the double stranded DNA in vitro compared to reduced form of GSH.