Vascular Endothelial Growth Factor and Cyclooxygenase-2 are Overexpressed in Ileal Pouch-Anal Anastomosis
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- 作者：Marco Romano ; Antonio Cuomo ; Concetta Tuccillo ; Raffaele Salerno ; Alba Rocco ; Stefania Staibano ; Massimo Mascolo ; Guido Sciaudone ; Caterina Mucherino and Antonio Giuliani ; et al.
- 关键词：Cell proliferation ; Cyclooxygenase ; 2 ; Ileal pouch ; anal anastomosis ; Neoangiogenesis ; Vascular endothelial growth factor
- 刊名：Diseases of the Colon & Rectum
- 出版年：2007
- 出版时间：May, 2007
- 年：2007
- 卷：50
- 期：5
- 页码：650-659
- 全文大小：513 KB
文摘
Purpose Pathophysiology of pouchitis after ileal pouch-anal anastomosis is controversial because of the potential for development of carcinoma. Cyclooxygenase-2-derived prostaglandins may be involved in the inflammatory process and play a role in the pathogenesis of colon cancer. Vascular endothelial growth factor plays a major role in neoangiogenesis and is overexpressed in a number of gastrointestinal malignancies. The goal of this study was to evaluate the expression of cyclooxygenase-2 and vascular endothelial growth factor and to assess neoangiogenesis and epithelial cell proliferation in patients with ileal pouch-anal anastomosis.