A novel helical micro-valve for embedded micro-fluidic applications

详细信息    查看全文

• 作者：Rajeev Kumar Singh ; Rishi Kant ; Sushant Singh ; E. Suresh…
• 关键词：Micro ; valve ; Polydimethyl siloxane (PDMS) ; Soft lithography ; COMSOL ; Microparticle image velocimetry (micro ; PIV)
• 刊名：Microfluidics and Nanofluidics
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：19
• 期：1
• 页码：19-29
• 全文大小：1,332 KB
• 参考文献：Barth PW (1995) Silicon microvalves for gas flow control. In: Proceedings of the 8th international conference on solid-state sensors and actuators (Transducers-5), pp 276-77
  Bhattacharya S, Singh RK, Mandal S, Ghosh A, Bok S, Korampally V, Gangopadhyay S (2010) Plasma modification of polymer surfaces and their utility in building biomedical microdevices. J Adhes Sci Technol 24(15-6):2707-739View Article
  Bown MR, MacInnes JM, Allen RWK (2005) Micro-PIV simulation and measurement in complex microchannel geometries. Meas Sci Technol 16:619-26View Article
  Chung CK, Shih TR, Wu BH (2009) Simulation of the novel microvalve using dynamic analysis. In: Proceedings of the 2009 4th IEEE international conference on nano/micro engineered and molecular systems, Shenzhen, China, pp 527-30
  Driggs BS, Enzelberger MM, Quake SR (2007) Electrostatic valves for microfluidic devices. US Patent 7,232,109, 19 June 2007
  Dy AJ, Cosmanescu A, Sluka J, Glazier JA, Stupack D, Amarie D (2014) Fabricating microfluidic valve mastermolds with SU8 photoresist. J Micromech Microeng 24:057001View Article
  Gómez-Sj?berg R, Leyrat AA, Pirone DM, Chen CS, Quake SR (2007) Versatile, fully automated, microfluidic cell culture system. Anal Chem 79(22):8557-563View Article
  Graf NJ, Bowser MT (2008) A soft-polymer piezoelectric bimorph cantilever-actuated peristaltic micropump. Lab Chip 8(10):1664-670View Article
  Kant R, Singh H, Nayak M (2013) Optimization of design and characterization of a novel micro-pumping system with peristaltic motion. Microsyst Technol 19:563-75View Article
  Lee JN, Park C, Whitesides GM (2003) Solvent compatibility of poly (dimethylsiloxane)-based microfluidic devices. Anal Chem 75(23):6544-554View Article
  Mohseni K, Dolatabadi A (2006) An electrowetting microvalve numerical simulation. Ann NY Acad Sci 1077:415-25View Article
  Nguyen NT, Truong TQ, Wong KK, Ho SS, Low CLN (2004) Micro check valves for integration into polymeric microfluidic devices. J Micromech Microeng 14(1):69View Article
  Pan T, McDonald SJ, Kai EM, Ziaie B (2005) A magnetically driven PDMS micropump with ball check-valves. J Micromech Microeng 15(5):1021View Article
  Park JY, Oh HJ, Kim DJ, Baek JY, Lee SH (2006) A polymeric microfluidic valve employing a pH-responsive hydrogel microsphere as an actuating source. J Micromech Microeng 16(3):656View Article
  Pemble CM, Towe BC (1999) A miniature shape memory alloy pinch valve. Sens Actuators A 77:145-48View Article
  Rogge T, Rummler Z, Schomburg WK (2004) Polymer micro valve with a hydraulic piezo-drive fabricated by the AMANDA process. Sens Actuators A 110:206-12View Article
  Sassetti F, Guarnieri FA, Garelli L, Storti MA (2011) Characterization and simulation of an active microvalve for glaucoma. Comput Methods Biomech Biomed Eng. doi:10.-080/-0255842.-011.-85978
  Silva G, Leal N, Semiao V (2008) Effect of wall roughness on fluid flow inside a microchannel. In: 14th International symposium on applications of laser techniques to fluid mechanics, Lisbon, Portugal, pp 1-3
  Singh RK, Kumar A, Kant R, Gupta A, Suresh E, Bhattacharya S (2013) Design and fabrication of 3-dimensional helical structures in polydimethylsiloxane for flow control applications. Microsyst Technol. doi:10.-007/?s00542-013-1738-7
  Studer V, Jameson R, Pellereau E, Pepin A, Chen Y (2004) A microfluidic mammalian cell sorter based on fluorescence detection. Microelectron Eng 73-4:852-57View Article
  Takao H, Miyamura K, Ebi H, Ashiki M, Sawada K, Ishida K (2005) A MEMS microvalve with PDMSdiaphragm and two-chamber configuration of thermo-pneumatic actuator for integrated blood test system on silicon. Sens Actuators A 119:468-75View Article
  Unger MA, Chou H-P, Thorsen T, Scherer A, Quake SR (2000) Monolithic microfabricated valves and pumps by multilayer lithography. Science 288:113View Article
  Vyawahare S, Sitaula S, Martin S, Adalian D, Scherer A (2008) Electronic control of elastomeric microfluidic circuits with shape memory actuators. Lab Chip 8(9):1530-535View Article
  Xia Y, Whitesides GM (1998) Soft lithography. Annu Rev Mater Sci 28(1):153-84View Article
  Yamahata C, Lacharme F, Gijs MA (2005) Glass valveless micropump using electromagnetic actuation. Microelectron Eng 78:132-37View Article
  Zou JX, Ye YZ, Zhou Y, Yang Y (1997) A novel thermally actuated silicon micropump. In: Proceedings of international symposium on micromechatronics and human science, Nagoya, Japan
  
• 作者单位：Rajeev Kumar Singh (1)
  Rishi Kant (1)
  Sushant Singh (1)
  E. Suresh (1)
  Ankur Gupta (1)
  Shantanu Bhattacharya (1)
  
  1. Microsystems Fabrication Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, 208 016, India
  
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

In this paper, we report a pneumatically actuated solenoid micro-valve with simulation, design and characterization. In micro-fluidic applications dealing with soft biological fluids very often, digital micro-valves [also known as Quake valves (Unger et al. in Science 288:113, 2000)] are deployed to start/stop flows in pressurized micro-channels. These valves are designed in a manner so that the actuation is performed by a control micro-channel filled with compressed air seating on the top of another micro-channel filled with fluidic sample. The response time of these valves is so miniscule that they almost close immediately qualifying them to be digital in nature. Still in applications like drug screening where a small amount of intermixing may have a counterintuitive effect on the whole experiment, the valves may underperform. In order to address the problem of leakages/leaching of fluids across a fully pressure-closed digital micro-valve, we have tried to incorporate a design modification with a completely different fabrication process, wherein the closing approach of a Quake valve has been varied from top down to radially inwards across the whole cross-section of the micro-channel. The design of this valve enables its wide applicability to embedded micro-fluidics, which is widely used to mimic/study the flow of body fluids across our vasculature or is highly useful for chip cooling applications. Micro-valving has been seldom explored in the embedded domain, and the current architecture of the micro-valve in a way fills this technology gap. In our design, two concentric hollow tracks, one straight and another helical are replicated in polydimethyl siloxane using preformed 80-micron copper wires that are of circular cross-section. Compressed oxygen is passed through the helical channel to control the fluid flow in the concentrically placed straight micro-channel. The micro-valve controls the fluid flow by applying uniform pressure homogeneously on micro-channel wall so that the wall can collapse and close the channel cross-section (stop condition). The system has been designed and simulated using COMSOL multi-physics platform where a design optimization was carried out in details in an earlier work (Singh et al. in Microsyst Technol. doi:10.-007/?s00542-013-1738-7, 2013). In this work, we have evaluated the design experimentally through monitoring the inlet/outlet flow rate in the central micro-channel through microparticle image velocimetry (micro-PIV) analysis on opened/closed valve conditions. A flow behavior of the central micro-channel is simulated using COMSOL multi-physics platform, and the pre/post-valving discharge have been estimated theoretically for various input flow rate conditions at a corresponding air pressure of 5?psi in the helical track. We have further validated this through micro-PIV experiments wherein the valving behavior observed is different to the extent of the transient flow part but quite similar as regards the steady-state part.