参考文献:Anuradha V, Srinivas PV, Ranga Rao R, Manjulatha K, Purohit MG, Madhusudana Rao J (2006) Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L. Bioorg Med Chem 14:6820鈥?826CrossRef PubMed Bohm BA (1998) Introduction to flavonoids. Gordon & Breach, Amsterdam Cazarolli LH, Zanatta L, Alberton EH, Figueiredo MSRB, Folador P, Damazio RG, Pizzolatti Silva FRMB (2008) Flavonoids: prospective drug candidates. Mini Rev Med Chem 8:1429鈥?440CrossRef PubMed Cook NC, Samman S (1996) Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 7:66鈥?6CrossRef Ferreira SB, da Silva FC, Bezerra FAFM, Lourenco MCS, Kaiser CR, Pinto AC, Ferreira VF (2010) Synthesis of 伪- and 尾-Pyran Naphthoquinones as a new class of antitubercular agents. Arch Pharm 343:81鈥?0 Fishkin RJ, Winslow JT (1997) Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs. Psychopharmacology (Berl) 132:335鈥?41CrossRef Habtemariam S (1997) Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-伪 in L-929 tumor cells. J Nat Prod 60:775鈥?78CrossRef PubMed Harborne JB, Baxter H (eds) (1999) The handbook of natural flavonoids UK, vol 1 and 2. Wiley, Chichester Havsteen BH (2002) The biochemistry and medical significance of the flavonoids. Pharm Ther 96:67鈥?02. http://鈥媤ww.鈥媟csb.鈥媜rg/鈥媝db Jones G, Willett P, Glen RC (1995) Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. J Mol Biol 245:43鈥?3CrossRef PubMed Jones G, Willett P, Glen RC, Leach AR, Taylor R (1997) Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267:727鈥?48CrossRef PubMed Keche AP, Hatnapure GD, Tale RT, Rodge AH, Birajdar SS, Kamble VM (2013) Synthesis, anti-inflammatory and antimicrobial evaluation of novel N 1-(quinolin-4-yl) ethane-1,2-diamine phenyl urea derivatives. Med Chem Res 22:1480鈥?487CrossRef Khafagy MM, El-Wahas AHFA, Eid FA et al (2002) Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities. Farmaco 57:715鈥?22CrossRef PubMed Kubo I, Kinst Hori I, Choudhuri SK, Kubo Y, Sanchez Y, Ogura T (2000) Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorg Med Chem 8:1749鈥?755CrossRef PubMed Lipniski CA, Lombardo F, Dommy BW, Feeney P (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. J Adv Drug Deliv Rev 46:3鈥?6CrossRef Liu YL, Ho DK, Cassady JM (1992) Isolation of potential cancer chemopreventive agents from Eriodictyon californicum. J Nat Prod 55:357鈥?63CrossRef PubMed Martinez AG, Marco LJ (1997) Friedl盲nder reaction on 2-amino-3-cyano-4H-pyrans: synthesis of derivatives of 4H-pyran[2,3-b]quinoline, new tacrine analogues. Bioorg Med Chem Lett 7:3165鈥?170CrossRef Menenzes JCJMDS, Kamat SP, Cavaleiro JAS, Gaspar A, Garrido J, Borges F (2011) Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates. Eur J Med Chem 46:773鈥?77CrossRef Messanga BB, Tih RG, Kimbu SF, Sondengam BL, Martin MT, Bodo B (1992) Calodenone, a New Isobiflavonoid from Ochna calodendron. J Nat Prod 55:245鈥?48CrossRef Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981鈥?002. J Nat Prod 66:1022鈥?037CrossRef PubMed Nishino T, Nishiyama Y, Sonoda Noboru (2003) Deoxygenative dimerization of benzylic and allylic alcohols, and their ethers and esters using lanthanum metal and chloro trimethylsilane in the presence of a catalytic amount of iodine and copper(I) iodide. Bull Chem Soc Jpn 76:635鈥?36CrossRef Nissink JWM, Murray C, Hartshorn M, Verdonk ML, Cole JC, Taylor R (2002) A new test set for validating predictions of protein鈥搇igand interaction. Proteins Struct Funct Bioinform 49:457鈥?71CrossRef Patel MA, Bhila VG, Patel NH, Patel AK, Brahmbhatt DI (2012) Synthesis, characterization and biological evaluation of some pyridine and quinoline fused chromenone derivatives. Med Chem Res 21:4381鈥?388CrossRef Pearce FL, Befs AD, Bienenstock J (1984) III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol 73:819鈥?23CrossRef PubMed Peng Cheng LV, Wang Kai Rui, Li Qing Shan, Chen Jin, Sun Juan, Zhu Hai Liang (2010) Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents. Bioorg Med Chem 18:1117鈥?123CrossRef Ranga Rao R, Tiwari AK, Reddy P, Suresh Babu K, Ali AZ, Madhusudana K, Madhusudana Rao J (2009) New furanoflavanoids, intestinal 伪-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.). Bioorg Med Chem 17:5170鈥?175CrossRef PubMed Shamroukh AH, Zaki MEA, Morsy EMH, Abdel-Motti FM, Abdel-Megeid FME (2007) Synthesis, isomerization, and antimicrobial evaluation of some pyrazolopyranotriazolo pyrimidine derivatives. Arch de Pharma 340:345鈥?51CrossRef Skibola CF, Smith MT (2000) Potential health impacts of excessive flavonoid intake. Free Radic Biol Med 29:375鈥?83CrossRef PubMed Sridhar R, Perumal PT, Etti S, Shanmugam G, Ponnuswamy MN, Prabavathyc VR, Mathivanan N (2004) Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates. Bioorg Med Chem Lett 14:6035鈥?040CrossRef PubMed Suresh Babu K, Hari Babu T, Srinivas PV, Hara Kishore K, Murthy USN, Madhusudana Rao J (2006) Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. Bioorg Med Chem Lett 16:221鈥?24CrossRef PubMed Trott O, Olson AJ (2010) Auto Dock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455鈥?61PubMed Central PubMed Van Acker SABE, Van Den Berg DJ, Tromp MNJL, Grioen DH, Van Bennekom WP, Van der Vijgh WJF, Bast A (1996) Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med 20:331鈥?42CrossRef PubMed Verdonk ML, Cole JC, Hartshorn MJ, Murray CW, Taylor RD (2003) Improved protein鈥搇igand docking using GOLD. Proteins Struct Funct Bioinform 52:609鈥?23CrossRef Vistoli G, Pedretti A, Testa B (2008) Assessing drug-likeness鈥攚hat are we missing? Drug Discov Today 13:285鈥?94CrossRef PubMed Vyas DH, Tala SD, Akbari JD, Dhaduk MF, Joshi KA, Joshi HS (2009) Synthesis and antimicrobial activity of some new cyanopyridine and cyanopyrans towards Mycobacterium tuberculosis and other microorganisms. Indian J Chem 48B:833鈥?39 Wolfman C, Viola H, Paladini A, Dajas F, Medina JH (1994) Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea. Pharmacol Biochem Behav 47:1鈥?CrossRef PubMed Xiao QZ, Sheng MP, Chang PH, Li FT, Han WD, Yuan JL (2011) Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculo protection. Bioorg Med Chem Lett 21:1222鈥?226CrossRef Yakaiah T, Kurumurthy C, Lingaiah PV, Narsaiah B, Velatooru R, Venkateshwarlu J, Gururaj S, Parthasarathy T, Sridhar B (2012) GdCl3 promoted synthesis of novel pyrimidine fused indazole derivatives and their anticancer activity. Med Chem Res 21(12):4261鈥?273CrossRef
作者单位:P. Ramesh (1) (4) Ch. Sanjeeva Reddy (2) K. Suresh Babu (3) P. Muralidhar Reddy (4) V. Srinivasa Rao (5) T. Parthasarathy (5)
1. Department of Chemistry, SR and BGNR Government College, Khammam, 507 002, India 4. Department of Chemistry, Nizams PG College, Osmania University, Hyderabad, 500 007, India 2. Department of Chemistry, Kakatiya University, Warangal, 506 009, India 3. Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India 5. Department of Chemistry, Osmania University, Hyderabad, 500 007, India