Antioxidant activity of synthetic analogs and pure active principles of rhodiola rosea and raspberry ketone

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• 作者：N. M. Storozhok (1)
  N. V. Gureeva (1)
  R. A. Khalitov (1)
  A. S. Storozhok (1)
  A. P. Krysin (2)
• 关键词：Antioxidants – ; tyrosol – ; analogs – ; α ; tocopherol – ; structure modification
• 刊名：Pharmaceutical Chemistry Journal
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：45
• 期：12
• 页码：732-735
• 全文大小：113.1 KB
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• 作者单位：1. Tyumen State Medical Academy, Tyumen, Russia2. Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, Russia
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Pharmacy
  Pharmacology and Toxicology
  Organic Chemistry
  Russian Library of Science
  
• 出版者：Springer New York
• ISSN：1573-9031

文摘

The antioxidant action of natural tyrosol derivatives, raspberry ketone, and their synthetic analogs was studied in comparison with α-tocopherol and butylhydroxytoluene. It is shown that hydroxylation of tyrosol increases the antioxidant activity 1.5 times. The introduction of one o-tert-butyl substituent increases the inhibiting action by a factor of 3.5; of two o-tert-butyl substituents, by greater than 4.0 times. The maximum inhibiting effect was observed for tert-butylhydroxytyrosol, the structural modification of which included simultaneously both hydroxylation and alkylation. The antioxidant activity of the studied substances was lower than that of α-tocopherol and butylhydroxytoluene. It was established that the induction periods of the studied antioxidants (AOs) in addition to many natural inhibitors (α-tocopherol, carotenoids, flavonoids) as functions of the concentrations of the studied AOs exhibit peaks. Thus, directed structural modifications of natural compounds yielded new effective oxidation inhibitors, the application of which will probably avoid undesired effects related to overdoses of the existing drugs.