Biodistribution Study of Intravenously Injected Cetuximab-IRDye700DX in Cynomolgus Macaques

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• 作者：E. de Boer ; S. Samuel ; D. N. French ; J. M. Warram…
• 刊名：Molecular Imaging and Biology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：18
• 期：2
• 页码：232-242
• 全文大小：3,491 KB
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• 作者单位：E. de Boer (1) (2)
  S. Samuel (3)
  D. N. French (3)
  J. M. Warram (1)
  T. R. Schoeb (4)
  E. L. Rosenthal (5)
  K. R. Zinn (3)
  
  1. Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
  2. Department of Surgery, University of Groningen, University Medical Centrum Groningen, Groningen, The Netherlands
  3. Department of Radiology, University of Alabama at Birmingham, Volker Hall G082, 1670 University Boulevard, Birmingham, AL, 35294, USA
  4. Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
  5. Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA
  
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002

文摘

Purpose The use of receptor-targeted antibodies conjugated to photosensitizers is actively being explored to enhance treatment efficacy. To facilitate clinical testing, we evaluated cetuximab conjugated to IRDye700DX (IR700) in cynomolgus macaques.