Small RNAs and RNAi pathways in meiotic prophase I

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• 作者：Rebecca J. Holmes and Paula E. Cohen
• 关键词：centromere ; chromatoid body ; meiosis ; piRNAs ; prophase I ; RNAi
• 刊名：Chromosome Research
• 出版年：2007
• 出版时间：July, 2007
• 年：2007
• 卷：15
• 期：5
• 页码：653-665
• 全文大小：282 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Human Genetics
  Animal Genetics and Genomics
  Plant Genetics and Genomics
  
• 出版者：Springer Netherlands
• ISSN：1573-6849

文摘

RNA interference is involved in many aspects of cell biology, and the recent identification of germ-cell specific small RNAs has led to speculation that RNAi might also be involved in gametogenesis. Work in yeast indicates that RNAi is involved in establishing and maintaining heterochromatin at centromeres, an important component of yeast and mammalian meiosis. Here we review developments in the field of RNAi and relate these to possible roles in mammalian gametogenesis.