Expression patterns of c-Fos early gene and phosphorylated ERK in the rat brain following 1-h immobilization stress: concomitant changes induced in association with stress-related sleep rebound

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• 作者：Fatemeh Keshavarzy ; Chantal Bonnet ; Gila Bezhadi…
• 关键词：Immobilization stress ; Immunohistochemistry ; p ; ERK and c ; Fos ; Sleep rebound
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：220
• 期：3
• 页码：1793-1804
• 全文大小：2,624 KB
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• 作者单位：Fatemeh Keshavarzy (1) (3)
  Chantal Bonnet (2)
  Gila Bezhadi (1)
  Raymond Cespuglio (2)
  
  1. Functional Neuroanatomy Laboratory, Physiology Department and Neuroscience Research Center, Faculty of Medicine, Shahid Beheshti Medical Sciences University, Evin, Tehran, Iran
  3. Physiology Department, Faculty of Medicine, Shiraz Medical Sciences University, Shiraz, Iran
  2. Neuroscience Research Center of Lyon (INSERM U1028, CNRS UMR5292 & UCBLyon1), University of Lyon, 8 Avenue Rockefeller, 69373, Lyon, France
  
• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

An immobilization stress (IS) of 1?h applied at the beginning of the dark phase is followed by a sleep rebound. During the restraint, serotonin released by the dorsal raphe nucleus within the arcuate area stimulates the availability of corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39). Three hours after the restraint, CLIP, through its hypnogenic properties, contributes to the sleep rebound that follows the IS. Here, we immunohistochemically evaluated protein expression of the immediate early gene, c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) in hypothalamic (preoptic area [POA], paraventricular nucleus [PVN], arcuate nucleus [ARC]) and brain stem (dorsal raphe [DR], locus coeruleus [LC]) nuclei involved in the acute response to stress and the subsequent stress-related sleep rebound (recovery period). Immediately after the 1-h restraint, c-Fos and p-ERK expression increased in all structures studied, particularly in PVN and LC. Three hours later, the number of p-ERK- and c-Fos-positive neurons was reduced in PVN and LC (p?<?0.001) as well as in DR (p?<?0.01) compared to control animals. In contrast, both c-Fos and p-ERK expression in POA neurons (p?<?0.01) and c-Fos expression in ARC neurons (p?<?0.001) were increased 3?h after the IS. The marked activation observed in PVN and LC nucleus immediately after the IS confirms that these structures are clearly reactive to stress. However, the high activity observed in POA and ARC neurons during the recovery period, not described to date, highlights the particular part played by these structures in the stress-related sleep rebound. An unbalance in the above processes may contribute to pathological outcomes, such as anxiety and depression.