Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica
详细信息    查看全文
  • 作者:Justin B. Greer ; Sawsan Khuri ; Lynne A. Fieber
  • 关键词:Kainate ; Real ; time PCR ; L ; glutamate ; Nervous system
  • 刊名:BMC Evolutionary Biology
  • 出版年:2017
  • 出版时间:December 2017
  • 年:2017
  • 卷:17
  • 期:1
  • 全文大小:3367KB
  • 刊物主题:Evolutionary Biology; Animal Systematics/Taxonomy/ Biogeography; Entomology; Genetics and Population Dynamics; Life Sciences, general;
  • 出版者:BioMed Central
  • ISSN:1471-2148
  • 卷排序:17
文摘
BackgroundThe neurotransmitter L-Glutamate (L-Glu) acting at ionotropic L-Glu receptors (iGluR) conveys fast excitatory signal transmission in the nervous systems of all animals. iGluR-dependent neurotransmission is a key component of the synaptic plasticity that underlies learning and memory. During learning, two subtypes of iGluR, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) and N-methyl-D-aspartate receptors (NMDAR), are dynamically regulated postsynaptically in vertebrates. Invertebrate organisms such as Aplysia californica (Aplysia) are well-studied models for iGluR-mediated function, yet no studies to date have analyzed the evolutionary relationships between iGluR genes in these species and those in vertebrates, to identify genes that may mediate plasticity. We conducted a thorough phylogenetic analysis spanning Bilateria to elucidate these relationships. The expression status of iGluR genes in the Aplysia nervous system was also examined.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700