Folate-Mediated Targeted Delivery of Combination Chemotherapeutics Loaded Reduced Graphene Oxide for Synergistic Chemo-Photothermal Therapy of Cancers

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• 作者：Raj Kumar Thapa ; Yongjoo Choi ; Jee-Heon Jeong ; Yu Seok Youn…
• 关键词：KEY WORDScombination chemotherapy ; docetaxel ; folic acid ; irinotecan ; reduced graphene oxide
• 刊名：Pharmaceutical Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：33
• 期：11
• 页码：2815-2827
• 全文大小：2,347 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X
• 卷排序：33

文摘

PurposeLarger surface area for drug incorporation and superior optical activity makes reduced graphene oxide (rGO) a suitable drug carrier for combination chemotherapeutics delivery. And folate receptors are potential mediators for cancer targeted delivery. This study mainly aimed to prepare irinotecan (IRI)- and docetaxel (DOC)-loaded, folate (FA)-conjugated rGO (FA-P407-rGO/ID) for synergistic cancer therapy.