Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy

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• 作者：Hadi Samadian ; Samira Hosseini-Nami…
• 关键词：Cancer ; Nanotechnology ; Targeting ; Folic acid ; Gold nanoparticles
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：142
• 期：11
• 页码：2217-2229
• 全文大小：1,299 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Internal Medicine
  Hematology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1335
• 卷排序：142

文摘

Conventional cancer treatment methods suffer from many limitations such as non-specificity and low efficacy in discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials that basically take advantage of various targeting approaches. Targeted nanomaterials selectively bind to the cancer cells and affect them with minor effects on healthy cells. Folic acid (folate) is an essential molecule in DNA synthesis pathway which is highly needed for cancer cell duplication. Some certain cancer cells overexpress folate receptors higher than normal cells, and this fact is the basis of folate targeting strategy. There are many publications reporting various folate conjugated nanomaterials among which folate-conjugated gold nanoparticles hold great promises in targeted cancer therapy. Gold nanoparticles have been identified as promising candidates for new cancer therapy modalities because of biocompatibility, easy synthesis and functionalization, chemo-physical stability, and optical tunable characteristics. In the last decade, there has been a significant explosion in gold nanoparticles research, with a rapid increase in publications related to the area of biomedicine. Although there are many reports published on “gold nanoparticles” and “folate targeting,” there are a few reports on “folate-conjugated gold nanoparticles” in biomedical literature. This paper intends to review and illustrate the recent advances in biomedicine which have been designed on the basis of folate-conjugated gold nanoparticles.