Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist

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• 作者：Rossella Canese ; Francesca Zoratto ; Luisa Altabella ; Paola Porcari…
• 关键词：Magnetic resonance spectroscopy ; DTI ; Functional connectivity ; Hippocampus ; Nucleus accumbens ; Amygdala ; Limbic loop ; Cortical loop ; Serotonin 7 receptor ; Anxiety
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：232
• 期：1
• 页码：75-89
• 全文大小：1,334 KB
• 参考文献：1. Adriani W, Boyer F, Leo D, Canese R, Podo F, Perrone-Capano C, Dreyer J-L, Laviola G (2010) Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in rats-accumbens. Int J Neuro-Psycho-Pharmacol 20:1-4
  2. Adriani W, Travaglini D, Lacivita E, Saso L, Leopoldo M, Laviola G (2012) Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. Neuropharmacology 62:833-42 CrossRef
  3. Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, “prefrontal-and “limbic-functions. Prog Brain Res 85:119-46 CrossRef
  4. Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4:316-29 CrossRef
  5. Auffermann WF, Ngan SC, Hu X (2002) Cluster significance testing using the bootstrap. Neuroimage 17:583-91 CrossRef
  6. Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209-19 CrossRef
  7. Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed 15:435-55 CrossRef
  8. Beique JC, Campbell B, Perring P, Hamblin MW, Walker P, Mladenovic L, Andrade R (2004) Serotonergic regulation of membrane potential in developing rat prefrontal cortex: coordinated expression of 5-hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 receptors. J Neurosci 24:4807-817 CrossRef
  9. Bevins RA, Besheer J (2006) Object recognition in rats and mice: a one trail non-matching-to sample learning task to study “recognition memory- Nat Protoc 1:1306-311 CrossRef
  10. Blumenfeld-Katzir T, Pasternak O, Dagan M, Assaf Y (2012) Diffusion MRI of structural brain plasticity induced by a learning and memory task. PLoS ONE 6:e20678 CrossRef
  11. Bonaventure P, Kelly L, Aluisio L, Shelton J, Lord B, Galici R, Miller K, Atack J, Lovenberg TW, Dugovic C (2007) Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. J Pharmacol Exp Ther 321:690-98 CrossRef
  12. Bourin M, Hascoet M (2003) The mouse light/dark box test. Eur J Pharmacol 463:55-5 CrossRef
  13. Brown GW (2002) Social roles, context and evolution in the origins of depression. J Health Social Behav 43:255-76 CrossRef
  14. Canese R, Adriani W, Marco EM, De Pasquale F, Lorenzini P, De Luca N, Fabi F, Podo F, Laviola G (2009) Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study. Psychopharmacology (Berl) 203:143-53 CrossRef
  15. Canese R, Marco EM, De Pasquale F, Podo F, Laviola G, Adriani W (2011) Differential response to specific 5-Ht(7) versus whole-serotonergic drugs in rat forebrains: A phMRI study. Neuroimage 58:885-94 CrossRef
  16. Canese R, Pisanu ME, Mezzanzanica D, Ricci A, Paris L, Bagnoli M, Valeri B, Spada M, Venditti M, Cesolini A, Rodomonte A, Giannini M, Canevari S, Podo F, Iorio E (2012) Characterisation of in-vivo ovarian cancer models by quantitative 1H magnetic resonance spectroscopy and diffusion-weigh
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale The serotonin 7 receptor (5-HT7-R) is part of a neuro-transmission system with a proposed role in neural plasticity and in mood, cognitive or sleep regulation. Objectives We investigated long-term consequences of sub-chronic treatment, during adolescence (43-5 to 47-9?days old) in rats, with a novel 5-HT7-R agonist (LP-211, 0 or 0.250?mg/kg/day). Methods We evaluated behavioural changes as well as forebrain structural/functional modifications by in vivo magnetic resonance (MR) in a 4.7?T system, followed by ex vivo histology. Results Adult rats pre-treated during adolescence showed reduced anxiety-related behaviour, in terms of reduced avoidance in the light/dark test and a less fragmented pattern of exploration in the novel object recognition test. Diffusion tensor imaging (DTI) revealed decreased mean diffusivity (MD) in the amygdala, increased fractional anisotropy (FA) in the hippocampus (Hip) and reduced axial (D||) together with increased radial (D⊿ diffusivity in the nucleus accumbens (NAcc). An increased neural dendritic arborization was confirmed in the NAcc by ex vivo histology. Seed-based functional MR imaging (fMRI) identified increased strength of connectivity within and between “limbic-and “cortical-loops, with affected cross-correlations between amygdala, NAcc and Hip. The latter displayed enhanced connections through the dorsal striatum (dStr) to dorso-lateral prefrontal cortex (dl-PFC) and cerebellum. Functional connection also increased between amygdala and limbic elements such as NAcc, orbito-frontal cortex (OFC) and hypothalamus. MR spectroscopy (1H-MRS) indicated that adolescent LP-211 exposure increased glutamate and total creatine in the adult Hip. Conclusions Persistent MR-detectable modifications indicate a rearrangement within forebrain networks, accounting for long-lasting behavioural changes as a function of developmental 5-HT7-R stimulation.