Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms
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- 作者：Kristi Luberg ; Rahel Park ; Elina Aleksejeva ; Tõnis Timmusk
- 关键词：TRKA ; NTRK1 ; 5′ RACE ; Glycosylation ; Nuclear localization ; Isoforms ; Alternative splicing
- 刊名：BMC Neuroscience
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：6,346 KB
- 刊物主题：Neurosciences; Neurobiology; Animal Models;
- 出版者：BioMed Central
- ISSN：1471-2202
文摘
Background Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also controls proliferation, differentiation and survival of many neuronal and non-neuronal cells. TRKA (also known as NTRK1) gene is a target of alternative splicing which can result in several different protein isoforms. Presently, three human isoforms (TRKAI, TRKAII and TRKAIII) and two rat isoforms (TRKA L0 and TRKA L1) have been described.