How does your kidney smell? Emerging roles for olfactory receptors in renal function

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• 作者：Blythe D. Shepard ; Jennifer L. Pluznick
• 关键词：Olfactory receptors ; Blood pressure ; Kidney ; Adenylate cyclase 3 ; Odorant receptor ; Ligand
• 刊名：Pediatric Nephrology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：31
• 期：5
• 页码：715-723
• 全文大小：563 KB
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• 作者单位：Blythe D. Shepard (1)
  Jennifer L. Pluznick (1)
  
  1. Johns Hopkins University School of Medicine, Baltimore, MD, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-198X

文摘

Olfactory receptors (ORs) are chemosensors that are responsible for one’s sense of smell. In addition to this specialized role in the nose, recent evidence suggests that ORs are also found in a variety of additional tissues including the kidney. As this list of renal ORs continues to expand, it is becoming clear that they play important roles in renal and whole-body physiology, including a novel role in blood pressure regulation. In this review, we highlight important considerations that are crucial when studying ORs and present the current literature on renal ORs and their emerging relevance in maintaining renal function.