Structure and activation of the TSH receptor transmembrane domain

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• 作者：Ricardo Núñez Miguel ; Jane Sanders ; Jadwiga Furmaniak…
• 关键词：Graves’ disease ; Glycoprotein hormones ; Glycoprotein hormone receptors ; TSHR structure ; Transmembrane domain structure ; TSHR activation
• 刊名：Autoimmunity Highlights
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：2017KB
• 刊物主题：Immunology;
• 出版者：Springer International Publishing
• ISSN：2038-3274
• 卷排序：8

文摘

PurposeThe thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or cleavage domain (CD) and a transmembrane domain (TMD). The binding arrangements between the TSHR LRD and the thyroid-stimulating autoantibody M22 or TSH have become available from the crystal structure of the TSHR LRD–M22 complex and a comparative model of the TSHR LRD in complex with TSH, respectively. However, the mechanism by which the TMD of the TSHR and the other glycoprotein hormone receptors (GPHRs) becomes activated is unknown.