Mix-and-matching as a promoter recognition mechanism by ECF σ factors
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- 作者：Jelena Guzina ; Marko Djordjevic
- 关键词：Bacterial promoters ; Transcription initiation ; σ70 family ; Mix ; and ; matching ; ECF σ factors
- 刊名：BMC Evolutionary Biology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：17
- 期：1-supp
- 全文大小：1078KB
- 刊物主题：Evolutionary Biology; Animal Systematics/Taxonomy/ Biogeography; Entomology; Genetics and Population Dynamics; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2148
- 卷排序：17
文摘
BackgroundTranscription initiation is in bacteria exhibited by different σ factors, most of which fall within σ70 family. This family is diverse, ranging from the housekeeping Group I (RpoDs), to Group IV (ECF) σ factors, that transcribe smaller regulons under more stringent conditions. RpoDs employ a kinetic mix-and-match mechanism, where promoter elements complement each other binding strengths in achieving sufficient transcription activity. On the other hand, it is assumed that ECF σs, which are the most distant from the housekeeping σ factors, cannot exhibit mix-and-matching. However, mix-and-matching for ECF σ factors was not quantitatively checked before, and recent results show a much larger flexibility in the promoter recognition by the members of this group.