Adenovirus-mediated GDF-5 promotes the extracellular matrix expression in degenerative nucleus pulposus cells
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- 作者：Xu-wei Luo ; Kang Liu ; Zhu Chen ; Ming Zhao…
- 关键词：Intervertebral disc ; Degeneration ; Growth and differentiation factor ; 5 (GDF ; 5) ; Adenovirus ; Gene therapy ; Nucleus pulposus
- 刊名：Journal of Zhejiang University SCIENCE B
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：17
- 期：1
- 页码：30-42
- 全文大小：1,545 KB
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Kang Liu (1)
Zhu Chen (1)
Ming Zhao (1)
Xiao-wei Han (1)
Yi-guang Bai (1)
Gang Feng (1)
1. Research Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital and the Second Clinical Institute of North Sichuan Medical College, Nanchong, 637000, China - 刊物主题：Biomedicine general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1862-1783
文摘
Objective To construct a recombinant adenovirus vector-carrying human growth and differentiation factor-5 (GDF-5) gene, investigate the biological effects of adenovirus-mediated GDF-5 (Ad-GDF-5) on extracellular matrix (ECM) expression in human degenerative disc nucleus pulposus (NP) cells, and explore a candidate gene therapy method for intervertebral disc degeneration (IDD).