Increased glomerulonephritis recurrence after living related donation
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- 作者：A. L. Kennard ; S. H. Jiang ; G. D. Walters
- 关键词：Kidney ; Donor ; Transplant ; Survival ; Glomerulonephritis ; Recurrence
- 刊名：BMC Nephrology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：1060KB
- 刊物主题：Nephrology; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2369
- 卷排序：18
文摘
BackgroundKidney transplantation confers superior outcomes for patients with end stage kidney disease, and live donor kidneys associate with superior outcomes compared to deceased donor kidneys. Modern immunosuppression has improved rejection rates and transplant survival and, as a result, recurrence of glomerulonephritis has emerged as a major cause of allograft loss. However, many glomerulonephritides have significant genetic risk which may manifest through kidney intrinsic or systemic mechanisms. We hypothesise that heritable kidney intrinsic predisposition to glomerulonephritis will result in increased risk of glomerulonephritis recurrence in kidneys transplanted from genetically related donors.