In situ forming chitosan-based hydrogel as a lung sealant for biological lung volume reduction

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• 作者：Titima Songkroh ; Hongguo Xie ; Weiting Yu ; Guojun Lv ; Xiudong Liu…
• 关键词：Chitosan ; based hydrogels ; Biological lung volume reduction ; Lung sealants ; Emphysema
• 刊名：Chinese Science Bulletin
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：60
• 期：2
• 页码：235-240
• 全文大小：576 KB
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• 刊物主题：Science, general; Life Sciences, general; Physics, general; Chemistry/Food Science, general; Earth Sciences, general; Engineering, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-9541

文摘

Biological lung volume reduction (BLVR) using lung sealant has received more attention recently as a new non-surgical approach to emphysema treatment. Many tissue sealants have been studied but only a few have been proposed for BLVR. In this work, we prepared in situ forming chitosan-based hydrogels (CSG) using covalent cross-linking of chitosan and genipin in the cooperation of ionic interaction between chitosan and sodium orthophosphate hydrate (Na3PO4·12H2O) and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and rheological methods. CSG showed short gelation time (8?min), high swelling ratio (>100?%) and non-toxicity (3T3 mouse fibroblast cell viability >80?%) under physiological conditions. The application of lung sealant for BLVR was tested in a Chinese dog and evaluated by chest computed tomography. After 3?weeks of the installation of CSG in bronchopulmonary segment, the gel formation was detected at a localized region of bronchi and the local atelectasis occurred. Our findings indicate that this chitosan-based hydrogel is a promising new candidate for use as a lung sealant for BLVR.