MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors

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• 作者：M. Braoudaki ; G. I. Lambrou ; S. A. Papadodima ; K. Stefanaki…
• 关键词：Pediatric ; Brain tumors ; MicroRNA microarrays ; qRT ; PCR ; Biomarkers ; ROC curves
• 刊名：Medical Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：33
• 期：1
• 全文大小：847 KB
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• 作者单位：M. Braoudaki (1) (2)
  G. I. Lambrou (1)
  S. A. Papadodima (3)
  K. Stefanaki (4)
  N. Prodromou (5)
  E. Kanavakis (1)
  
  1. University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, “Aghia Sophia” Children’s Hospital, University of Athens, Athens, Greece
  2. First Department of Pediatrics, Hematology and Oncology Unit, Choremeio Research Laboratory, “Aghia Sophia” Children’s Hospital, University of Athens Medical School, Thivon and Levadias, 11527, Goudi, Athens, Greece
  3. Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens, Athens, Greece
  4. Department of Pathology, Children’s Hospital “Aghia Sophia”, Athens, Greece
  5. Department of Neurosurgery, Children’s Hospital “Aghia Sophia”, Athens, Greece
  
• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

Among noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions. The diagnostic value of several miRNAs was appraised in pediatric dysembryoplastic neuroepithelial tumors (DNETs) using miRNA microarrays and receiving operating characteristic curves analyses. Overall, five pediatric DNETs were studied. As controls, 17 samples were used: the FirstChoice Human Brain Reference RNA and 16 samples from deceased children who underwent autopsy and were not present with any brain malignancy. The miRNA extraction was carried out using the mirVANA miRNA Isolation Kit, while the experimental approach included miRNA microarrays covering 1211 miRNAs. Quantitative real-time polymerase chain reaction was performed to validate the expression profiles of miR-1909* and miR-3138 in all samples initially screened with miRNA microarrays. Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric DNETs compared to the control cohort. Subsequently, both miRNA signatures might serve as putative diagnostic biomarkers for pediatric DNETs.