Corneal regeneration after femtosecond laser small-incision lenticule extraction: a prospective study

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• 作者：Manli Liu ; Ting Zhang ; Yugui Zhou ; Yuan Sun…
• 关键词：Small ; incision lenticule extraction ; Corneal regeneration ; In ; vivo confocal microscopy ; Three ; dimensional optical coherence tomography
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：253
• 期：7
• 页码：1035-1042
• 全文大小：2,115 KB
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  16.Teus MA, Garcia-Gonzalez M (2014) Comparison of the visual results after small incision lenticule extraction and femtosecond laser-assisted LASIK for myopia. J Refract Surg 30:582. doi:10.-928/-081597X-20140814-05 PubMed View Article
  17.Sekundo W, Gertnere J, Bertelmann T, Solomatin I (2014) One-year refractive results, contrast sensitivity, high-order aberrations and complications after myopic small-incision lenticule extraction (ReLEx SMILE). Graefes Arch Clin Exp Ophthalmol 252:837-43. doi:10.-007/?s00417-014-2608-4 PubMed View Article
  
• 作者单位：Manli Liu (1)
  Ting Zhang (1)
  Yugui Zhou (1)
  Yuan Sun (1)
  Danyang Wang (1)
  Hua Zheng (1)
  Quan Liu (1)
  
  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou, 510060, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-702X

文摘

Purpose To evaluate the morphologic changes of corneal after small incision lenticule extraction (SMILE) using the Heidelberg Retina Tomograph III (HRT III)/Rostock Cornea Module confocal microscope and three-dimensional optical coherence tomography (3D-OCT). Methods Thirty eyes of 30 patients who underwent SMILE for the correction of myopia and myopic astigmatism in this study. Morphologic modifications of corneal architecture and the density of corneal subbasal nerve were evaluated prior to SMILE and 7?days, 1, 3, and 6?months after SMILE by in-vivo confocal microscopy (IVCM) and 3D-OCT. Results The corneal epithelium morphology showed no particular changes during the entire 6-month examination period. Subbasal nerve density recovered to preoperative levels within 3?months after SMILE (P-gt;-.05). On the interface layer, intense keratocyte activity was noted in all eyes after SMILE. The corneal fibrotic tissues on the interface layer diminished with time, but the persistence of brightly reflective particles still existed. No particular change between preoperative and postoperative corneal endothelium. The incision margin of SMILE had the appearance of a less clearly identified fibrotic scar with epithelial plug. Conclusions IVCM and 3D-OCT analysis showed that there is a low-level corneal wound-healing response after SMILE procedure in the early postoperative period. Subbasal nerve regeneration is recovered at the third month, but the reflective particles elevated up to the sixth month.