Do osteoporotic fractures constitute a greater recalcitrant challenge for skeletal regeneration? Investigating the efficacy of BMP-7 and zoledronate treatment of diaphyseal fractures in an open fracture osteoporotic rat model
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- 作者：N. Mathavan ; M. Tägil ; H. Isaksson
- 关键词：Bmp ; 7 ; Fracture healing ; Osteoporosis ; Ovariectomy ; Zoledronate
- 刊名：Osteoporosis International
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：28
- 期：2
- 页码：697-707
- 全文大小：1512KB
- 刊物类别：Medicine
- 刊物主题：Orthopedics; Endocrinology; Rheumatology;
- 出版者：Springer London
- ISSN：1433-2965
- 卷排序：28
文摘
SummaryOsteoporotic fractures may pose a challenge for skeletal regeneration. This study investigates if pharmaceutical interventions such as bone morphogenetic protein 7 (BMP-7) alone or in combination with Zoledronate have equivalent efficacy in osteoporotic bone? Our findings suggest they do and that an osteoporotic bone environment may increase sensitivity to BMP-7.