Myelinated and unmyelinated nerve fibers reinnervate tissue-engineered dermo-epidermal human skin analogs in an in vivo model

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• 作者：T. Biedermann ; A. S. Klar ; S. Böttcher-Haberzeth…
• 关键词：Tissue engineering ; Peripheral nerve regeneration ; Human skin substitutes
• 刊名：Pediatric Surgery International
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：12
• 页码：1183-1191
• 全文大小：2,050 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  Surgery
  Pediatric Surgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-9813
• 卷排序：32

文摘

PurposeThe clinical application of autologous tissue-engineered skin analogs is an important strategy to cover large skin defects. Investigating biological dynamics, such as reinnervation after transplantation, is essential to improve the quality of such skin analogs. Previously, we have examined that our skin substitutes are reinnervated by host peripheral nerve fibers as early as 8 weeks after transplantation. Here, we wanted to investigate the presence and possible differences regarding myelinated and unmyelinated host nerve fibers 15 weeks after the transplantation of light and dark human tissue-engineered skin analogs.