Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle

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• 作者：Mohammed K Abo-Ismail (1) (2)
  Gordon Vander Voort (1)
  James J Squires (1)
  Kendall C Swanson (1) (3)
  Ira B Mandell (1)
  Xiaoping Liao (4)
  Paul Stothard (4)
  Stephen Moore (5)
  Graham Plastow (4)
  Stephen P Miller (1) (4) (5) (6)
  
• 关键词：Candidate genes ; Single nucleotide polymorphism ; Feed efficiency ; Carcass traits
• 刊名：BMC Genetics
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：271 KB
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• 作者单位：Mohammed K Abo-Ismail (1) (2)
  Gordon Vander Voort (1)
  James J Squires (1)
  Kendall C Swanson (1) (3)
  Ira B Mandell (1)
  Xiaoping Liao (4)
  Paul Stothard (4)
  Stephen Moore (5)
  Graham Plastow (4)
  Stephen P Miller (1) (4) (5) (6)
  
  1. Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G 2W0, Canada
  2. Department of Animal and Poultry Science, Damanhour University, Damanhour, Egypt
  3. Animal Sciences Department, North Dakota State University, Fargo, ND, USA
  4. Livestock Gentec, University of Alberta, Edmonton, AB, Canada
  5. Queensland Alliance Agr & Food Innovation, University of Queensland, St Lucia, Qld, 4072, Australia
  6. Animal and Poultry Science Department, Ontario Agriculture College, University of Guelph, 50 Stone Road, Guelph, ON, N1G 2W1, Canada
  
• ISSN：1471-2156

文摘

Background This study was conducted to: (1) identify new SNPs for residual feed intake (RFI) and performance traits within candidate genes identified in a genome wide association study (GWAS); (2) estimate the proportion of variation in RFI explained by the detected SNPs; (3) estimate the effects of detected SNPs on carcass traits to avoid undesirable correlated effects on these economically important traits when selecting for feed efficiency; and (4) map the genes to biological mechanisms and pathways. A total number of 339 SNPs corresponding to 180 genes were tested for association with phenotypes using a single locus regression (SLRM) and genotypic model on 726 and 990 crossbred animals for feed efficiency and carcass traits, respectively. Results Strong evidence of associations for RFI were located on chromosomes 8, 15, 16, 18, 19, 21, and 28. The strongest association with RFI (P--.0017) was found with a newly discovered SNP located on BTA 8 within the ELP3 gene. SNPs rs41820824 and rs41821600 on BTA 16 within the gene HMCN1 were strongly associated with RFI (P--.0064 and P--.0033, respectively). A SNP located on BTA 18 within the ZNF423 gene provided strong evidence for association with RFI (P--.0028). Genomic estimated breeding values (GEBV) from 98 significant SNPs were moderately correlated (0.47) to the estimated breeding values (EBVs) from a mixed animal model. The significant (P-lt;-.05) SNPs (98) explained 26% of the genetic variance for RFI. In silico functional analysis for the genes suggested 35 and 39 biological processes and pathways, respectively for feed efficiency traits. Conclusions This study identified several positional and functional candidate genes involved in important biological mechanisms associated with feed efficiency and performance. Significant SNPs should be validated in other populations to establish their potential utilization in genetic improvement programs.