LncRNAs, lost in translation or licence to regulate?

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• 作者：Alvaro de Andres-Pablo ; Antonin Morillon ; Maxime Wery
• 关键词：LncRNA ; Non ; coding genome ; RNA decay ; Regulatory RNA ; Transcription ; Translation
• 刊名：Current Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：63
• 期：1
• 页码：29-33
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Microbial Genetics and Genomics; Microbiology; Biochemistry, general; Cell Biology; Plant Sciences; Proteomics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0983
• 卷排序：63

文摘

Over the last decade, advances in transcriptomics have revealed that the pervasive transcription of eukaryotic genomes produces plethora of long noncoding RNAs (lncRNAs), which are now recognized as major regulators of multiple cellular processes. Although they have been thought to lack any protein-coding potential, recent ribosome-profiling data indicate that lncRNAs can interact with the translation machinery, leading to the production of functional peptides in some cases. In this perspective, we have explored the idea that translation can be part of the fate of cytoplasmic lncRNAs, raising the possibility for them to work as bifunctional RNAs, endowed with dual coding and regulatory functions.