The significance of aortic valve calcification in patients with bicuspid aortic valve disease

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• 作者：Xinshuang Ren ; Minghui Zhang ; Kun Liu…
• 关键词：Bicuspid aortic valve ; Aortic stenosis ; Aortic valve calcification
• 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：32
• 期：3
• 页码：471-478
• 全文大小：710 KB
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• 作者单位：Xinshuang Ren (1)
  Minghui Zhang (2)
  Kun Liu (1)
  Zhihui Hou (1)
  Yang Gao (1)
  Weihua Yin (1)
  Zhiqiang Wang (3)
  Zhennan Li (1)
  Bin Lu (1)
  
  1. Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
  2. Department of Ultrasound, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
  3. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Beijing, 100029, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-0743

文摘

Bicuspid aortic valve (BAV) is a common congenital heart disease. Our study was to analyze clinical features of BAV and evaluate whether aortic valve calcium score (AVCS) was a reliable marker for aortic stenosis (AS) in patients with BAV. 101 patients with BAV who both underwent echocardiology and cardiac computed tomography (CT) scan in our institution were included. Basic clinical data, haemodynamic feature, aortic valve and coronary calcium score were collected and compared among patients with different valve function and different degree of AS. Risk factors related to severe AS were evaluated by logistic regression, and a receiver operative characteristic curve was used to determine the cutoff calcium score greater than which the diagnosis of severe AS was optimized. Patients with aortic regurgitation (AR) were younger and demonstrated larger aortic annulus and sinus compared with patients with other valve dysfunction. Aortic valve calcium score was higher in patients with AS than with AR. For patients with different degree of AS, there were statistical significances in the value of age, aortic valve calcium score and coronary calcium score. AVCS was positively related to severe AS with an odd ratio of 1.286 (95 % CI 1.099–1.504) by every 300 points increase. AVCS was also a strong predictor for severe AS with area under the curve 0.855 with a cutoff value of 897 (sensitivity 86.7 %, specificity 72.2 %). Conclusively, aortic calcium score calculated by quantitative CT is a reliable marker in evaluating severity of AS. Keywords Bicuspid aortic valve Aortic stenosis Aortic valve calcification