Regional homogeneity alterations differentiate between tremor dominant and postural instability gait difficulty subtypes of Parkinson's disease

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• 作者：Siming Jiang ; Min Wang ; Li Zhang ; Yongsheng Yuan…
• 关键词：Parkinson’s disease ; Regional homogeneity ; Postural instability gait difficulty ; Tremor ; dominant
• 刊名：Journal of Neural Transmission
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：123
• 期：3
• 页码：219-229
• 全文大小：1,617 KB
• 参考文献：Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Prog Brain Res 85:119–146CrossRef PubMed
  Alon G, Yungher DA, Shulman LM, Rogers MW (2012) Safety and immediate effect of noninvasive transcranial pulsed current stimulation on gait and balance in Parkinson disease. Neurorehabil Neural Repair 26:1089–1095CrossRef PubMed
  Auyeung M, Tsoi TH, Mok V, Cheung CM, Lee CN, Li R, Yeung E (2012) Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson’s disease patients. J Neurol Neurosurg Psychiatry 83:607–611CrossRef PubMed
  Benninger DH, Thees S, Kollias SS, Bassetti CL, Waldvogel D (2009) Morphological differences in Parkinson’s disease with and without rest tremor. J Neurol 256:256–263CrossRef PubMed
  Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537–541CrossRef PubMed
  Bohnen NI, Koeppe RA, Minoshima S, Giordani B, Albin RL, Frey KA, Kuhi DE (2011) Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study. J Nucl Med 52:848–855CrossRef PubMed
  Cardoso EF et al (2010) Abnormal visual activation in Parkinson’s disease patients. Mov Disord 25:1590–1596CrossRef PubMed
  Choe IH, Yeo S, Chung KC, Kim SH, Lim S (2013) Decreased and increased cerebral regional homogeneity in early Parkinson’s disease. Brain Res 1527:230–237CrossRef PubMed
  Drew T, Prentice S, Schepens B (2004) Cortical and brainstem control of locomotion. Prog Brain Res 143:251–261CrossRef PubMed
  Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB: a frontal assessment battery at bedside. Neurology 55:1621–1626CrossRef PubMed
  Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198CrossRef PubMed
  Garcia-Garcia D et al (2012) Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson’s disease. Eur J Nucl Med Mol Imaging 39:1767–1777CrossRef PubMed
  Giladi N, Shabtai H, Simon ES, Biran S, Tal J, Korczyn AD (2000) Construction of freezing of gait questionnaire for patients with Parkinsonism. Parkinsonism Relat Disord 6:165–170CrossRef PubMed
  Grafton ST (2004) Contributions of functional imaging to understanding parkinsonian symptoms. Curr Opin Neurobiol 14:715–719CrossRef PubMed
  Helmich RC, de Lange FP, Bloem BR, Toni I (2007) Cerebral compensation during motor imagery in Parkinson’s disease. Neuropsychologia 45:2201–2215CrossRef PubMed
  Helmich RC, Hallett M, Deuschl G, Toni I, Bloem BR (2012) Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits. Brain 135:3206–3226PubMedCentral CrossRef PubMed
  Herman T, Rosenberg-Katz K, Jacob Y, Auriel E, Gurevich T, Giladi N, Hausdorff JM (2013) White matter hyperintensities in Parkinson’s disease: do they explain the disparity between the postural instability gait difficulty and tremor dominant subtypes? PLoS One 8:e55193PubMedCentral CrossRef PubMed
  Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184PubMedCentral CrossRef PubMed
  Jacobs JV, Horak FB (2007) Cortical control of postural responses. J Neural Transm 114:1339–1348PubMedCentral CrossRef PubMed
  Jankovic J et al (1990) Variable expression of Parkinson’s disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology 40:1529–1534CrossRef PubMed
  Kegelmeyer DA, Kloos AD, Thomas KM, Kostyk SK (2007) Reliability and validity of the Tinetti Mobility Test for individuals with Parkinson disease. Phys Ther 87:1369–1378CrossRef PubMed
  Kelly VE et al (2015) Association of cognitive domains with postural instability/gait disturbance in Parkinson’s disease. Parkinsonism Relat Disord 21:692–697CrossRef PubMed
  Lewis SJ, Barker RA (2009) A pathophysiological model of freezing of gait in Parkinson’s disease. Parkinsonism Relat Disord 15:333–338CrossRef PubMed
  Long XY et al (2008) Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods 171:349–355CrossRef PubMed
  Middleton FA, Strick PL (2001) Cerebellar projections to the prefrontal cortex of the primate. J Neurosci 21:700–712PubMed
  Mito Y, Yoshida K, Yabe I, Makino K, Tashiro K, Kikuchi S, Sasaki H (2006) Brain SPECT analysis by 3D-SSP and phenotype of Parkinson’s disease. J Neurol Sci 241:67–72CrossRef PubMed
  Mure H et al (2011) Parkinson’s disease tremor-related metabolic network: characterization, progression, and treatment effects. Neuroimage 54:1244–1253PubMedCentral CrossRef PubMed
  Playford ED, Jenkins IH, Passingham RE, Nutt J, Frackowiak RS, Brooks DJ (1992) Impaired mesial frontal and putamen activation in Parkinson’s disease: a positron emission tomography study. Ann Neurol 32:151–161CrossRef PubMed
  Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142–2154PubMedCentral CrossRef PubMed
  Rosenberg-Katz K, Herman T, Jacob Y, Giladi N, Hendler T, Hausdorff JM (2013) Gray matter atrophy distinguishes between Parkinson disease motor subtypes. Neurology 80:1476–1484PubMedCentral CrossRef PubMed
  Sage MD, Almeida QJ (2010) A positive influence of vision on motor symptoms during sensory attention focused exercise for Parkinson’s disease. Mov Disord 25:64–69CrossRef PubMed
  Sambataro F, Murty VP, Callicott JH, Tan HY, Das S, Weinberger DR, Mattay VS (2010) Age-related alterations in default mode network: impact on working memory performance. Neurobiol Aging 31:839–852PubMedCentral CrossRef PubMed
  Schepens B, Stapley P, Drew T (2008) Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independently. J Neurophysiol 100:2235–2253CrossRef PubMed
  Shumway-Cook A, Brauer S, Woollacott M (2000) Predicting the probability for falls in community-dwelling older adults using the timed up & go test. Phys Ther 80:896–903PubMed
  Tessitore A et al (2012a) Resting-state brain connectivity in patients with Parkinson’s disease and freezing of gait. Parkinsonism Relat Disord 18:781–787CrossRef PubMed
  Tessitore A et al (2012b) Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease. Neurology 79:2226–2232CrossRef PubMed
  Timmermann L, Gross J, Dirks M, Volkmann J, Freund HJ, Schnitzler A (2003) The cerebral oscillatory network of parkinsonian resting tremor. Brain 126:199–212CrossRef PubMed
  Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in parkinson’s disease. Mov Disord 25:2649–2685CrossRef PubMed
  Uc EY, Rizzo M, Anderson SW, Qian S, Rodnitzky RL, Dawson JD (2005) Visual dysfunction in Parkinson disease without dementia. Neurology 65:1907–1913CrossRef PubMed
  Zhang J, Wei L, Hu X, Xie B, Zhang Y, Wu GR, Wang J (2015) Akinetic-rigid and tremor-dominant Parkinson’s disease patients show different patterns of intrinsic brain activity. Parkinsonism Relat Disord 21:23–30CrossRef PubMed
  Zuo XN et al (2013) Toward reliable characterization of functional homogeneity in the human brain: preprocessing, scan duration, imaging resolution and computational space. Neuroimage 65:374–386PubMedCentral CrossRef PubMed
  
• 作者单位：Siming Jiang (1)
  Min Wang (2)
  Li Zhang (1)
  Yongsheng Yuan (1)
  Qing Tong (1)
  Jian Ding (1)
  Jianwei Wang (2)
  Qinrong Xu (1)
  Kezhong Zhang (1)
  
  1. Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China
  2. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Neurology
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Wien
• ISSN：1435-1463

文摘

Parkinson’s disease (PD) can be classified into the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD) subtype, which present with different clinical courses and prognoses. However, the symptom-specific intrinsic neural mechanisms underlying the subtypes of PD still remain elusive. In the current study, we utilized resting-state fMRI (rs-fMRI) combined with the regional homogeneity (ReHo) method to investigate the modulations of neural activity in 13 patients with predominantly PIGD (p-PIGD) and 15 patients with predominantly TD (p-TD) in the resting state. Compared with healthy controls, the p-PIGD and the p-TD groups both displayed ReHo changes in the default mode network (DMN). By contrast, the p-TD group exhibited more ReHo alterations in the cerebellum involved in the cerebello-thalamo-cortical (CTC) loops, whilst the p-PIGD group in extensive cortical and sub-cortical areas, including the frontal, parietal, occipital, temporal, limbic lobes, basal ganglia and thalamus, which are involved in the striatal-thalamo-cortical (STC) loops. Direct comparison between the two groups showed significant ReHo alterations in the primary visual cortex. Our findings underscore the differential involvement of the STC and CTC circuits underlying the two subtypes of PD. Moreover, relatively widespread neural activity abnormality, especially in the motor-related regions as well as the visual network, is apparently a characteristic feature of PIGD symptoms. This study could shed light on the underlying pathophysiology and clinical heterogeneity of PD presentation.