Effects of long-term topical anti-glaucoma medications on meibomian glands

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• 作者：Reiko Arita (12) ritoh@za2.so-net.ne.jp
  Kouzo Itoh (1)
  Shuji Maeda (3)
  Koshi Maeda (3)
  Ayumu Furuta (3)
  Atsuo Tomidokoro (2)
  Makoto Aihara (2)
  Shiro Amano (2)
• 关键词：Meibomian gland – ; Anti ; glaucomatous eye drop – ; Tear film
• 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
• 出版年：2012
• 出版时间：August 2012
• 年：2012
• 卷：250
• 期：8
• 页码：1181-1185
• 全文大小：278.9 KB
• 参考文献：1. Van Buskirk EM (1979) Corneal anesthesia after timolol maleate therapy. Am J Ophthalmol 88(4):739–743
  2. Van Buskirk EM (1980) Adverse reactions from timolol administration. Ophthalmology 87(5):447–450
  3. Weissman SS, Asbell PA (1990) Effects of topical timolol (0.5%) and betaxolol (0.5%) on corneal sensitivity. Br J Ophthalmol 74(7):409–412
  4. Wilson RP, Spaeth GL, Effie P (1980) The place of timolol in the practice of ophthalmology. Ophthalmology 87:451–454
  5. Alm A, Stjernschantz J (1995) The Scandinavian latanoprost study group. Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. Ophthalmology 102:1743–1752
  6. Watson P, Stjernschantz J (1996) The latanoprost study group. A six-month, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension. Ophthalmology 103:126–137
  7. Camras CB (1996) The United States Latanoprost Study Group. Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma. Ophthalmology 103:138–147
  8. Kuppens EVMJ, Stolwijk TR, de Keizer RJW, van Best JA (1992) Basal tear turnover and topical timolol in glaucoma patients and healthy controls by fluorophotometry. Invest Ophthalmol Vis Sci 33:3442–3448
  9. Herreras JM, Pastor JC, Calonge M, Asensio VM (1992) Ocular surface alteration after long-term treatment with an antiglaucomatous drug. Ophthalmology 99:1082–1088
  10. Arici MK, Arici DS, Topalkara A, G眉ler C (2000) Adverse effects of topical anti-glaucoma drugs on the ocular surface. Clin Exp Ophthalmol 28:113–117
  11. Thygesen J, Aaen K, Theodorsen F, Kessing SV, Prause JU (2000) Short-term effect of latanoprost and timolol eye drops on tear fluid and the ocular hypertension. Acta Ophthalmol Scand 78:37–41
  12. Sherwood MB, Grierson I, Millar L, Hitchings RA (1989) Long-term morphologic effects of antiglaucomatous drugs on the conjunctiva and Tenon’s capsule in glaucoma patients. Ophthalmology 96:327–335
  13. Baudouin C, Garcher C, Haouat N, Bron A, Gastaud P (1994) Expression of inflammatory membrane markers by conjunctival cells in chronically treated patients with glaucoma. Ophthalmology 101(3):454–460
  14. Baudouin C, Liang H, Hamard P, Riancho L, Creuzot-Garcher C, Warnet JM, Brignole-Baudouin F (2008) The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways. Ophthalmology 115(1):109–115
  15. Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX (2003) Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther 19(6):501–515
  16. Ota T, Murata H, Sugimoto E, Aihara M, Araie M (2005) Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation. Invest Ophthalmol Vis Sci 46(6):2006–2011
  17. Burstein NL (1985) The effects of topical drugs and preservatives on the tears and corneal epithelium in dry eye. Trans Ophthalmol Soc UK 104:402–409
  18. Baudouin C, de Lunardo C (1998) Short-term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers. Br J Ophthalmol 82(1):39–42
  19. Norm MS, Opauszki A (1977) Effects of ophthalmic vehicles on the stability of the precorneal tear film. Acta Ophthalmol 55:23–32
  20. Yalva莽 IS, Gedikoğlu G, Karag枚z Y, Akg眉n U, Nur枚zler A, Ko莽 F, Kasim R, Duman S (1995) Effects of antiglaucoma drugs on ocular surface. Acta Ophthalmol Scand 73(3):246–248
  21. Kuppens EV, van Best JA, Sterk CC, de Keizer RJ (1995) Decreased basal tear turnover in patients with untreated primary open-angle glaucoma. Am J Ophthalmol 120(1):41–46
  22. Kuppens EV, de Jong CA, Stolwijk TR, de Keizer RJ, van Best JA (1995) Effect of timolol with and without preservative on the basal tear turnover in glaucoma. Br J Ophthalmol 79(4):339–342
  23. Wilson WS, Duncan AJ, Jay JL (1975) Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man. Br J Ophthalmol 59:667–669
  24. Arita R, Itoh K, Inoue K, Amano S (2008) Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology 115:911–915
  25. Shimazaki J, Goto E, Ono M, Shimmura S, Tsubota K (1998) Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmol 105:1485–1488
  26. Leung EW, Medeiros FA, Weinreb RN (2008) Prevalence of ocular surface disease in glaucoma patients. J Glaucoma 17(5):350–355
  27. Inoue K, Okugawa K, Kato S, Inoue Y, Tomita G, Oshika T, Amano S (2003) Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy. J Glaucoma 12(6):480–485
  28. Brandt JD, Wittpenn JR, Katz LJ, Steinmann WN, Spaeth GL (1991) Conjunctival impression cytology in patients with glaucoma using long-term topical medication. Am J Ophthalmol 112(3):297–301
  29. Broadway DC, Grierson I, O’Brien C, Hitchings RA (1994) Adverse effects of topical antiglaucoma medication. I. The conjunctival cell profile. Arch Ophthalmol 112(11):1437–1445
  30. Baudouin C, de Lunardo C (1998) Short term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers. Br J Ophthalmol 82:39–42
  31. Jester JV, Nicolaides N, Smith R (1981) Meibomian gland studies: histologic and ultrastructural investigations. Invest Ophthalmol Vis Sci 20:537–547
  32. Nicolaides N, Santos EC, Smith RE, Jester JV (1989) Meibomian gland dysfunction, III: meibomian gland lipids. Invest Ophthalmol Vis Sci 30:946–951
  33. Arita R, Itoh K, Maeda S, Maeda K, Furuta A, Tomidokoro A, Amano S (2010) Meibomian gland duct distortion in patients with perennial allergic conjunctivitis. Cornea 29:858–860
  34. Burstein NL (1980) Preservative cytotoxic threshold for benzalkonium chloride and chlorhexidine digluconate in cat and rabbit corneas. Invest Ophthalmol Vis Sci 19(3):308–313
  35. Pauly A, Meloni M, Baudouin FB, Warnet JM, Baudouin C (2009) Multiple endpoint analysis of the 3D-reconstituted corneal epithelium after treatment with benzalkonium chloride: early detection of toxic damage. Invest Ophthalmol Vis Sci 50(4):1644–1652
  36. Ishibashi T, Yokoi N, Kinoshita S (2003) Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride. J Glaucoma 12(6):486–490
• 作者单位：1. Itoh Clinic, 626-11 Minaminakano, Minuma-ku, Saitama City, Saitama 337-0042, Japan2. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan3. Maeda Ophthalmic Clinic, Fukushima, Japan
• ISSN：1435-702X

文摘

Objective To examine effects of long-term topical anti-glaucoma medications on meibomian gland morphology and function and assess their relationship with slit-lamp findings.