Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment
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- 作者：Maximilian Fleischmann ; Ulf Schnetzke…
- 关键词：AML ; FLT3 ; ITD ; Allogeneic transplantation ; Tyrosine kinase inhibitor
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：143
- 期：2
- 页码：337-345
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
BackgroundActivating mutations of the receptor tyrosine kinase FLT3 (fms-related tyrosine kinase 3) reflect the most frequent molecular aberration in acute myeloid leukemia (AML). In particular, FLT3 internal tandem duplications (FLT3-ITD) are characterized by an unfavorable prognosis and allogeneic stem cell transplantation (allogeneic SCT) in first complete remission is recommended. In case of imminent or frank relapse following allogeneic SCT, treatment with FLT3 tyrosine kinase inhibitors (TKI) constitutes a promising clinical approach to induce hematologic remission without conventional chemotherapy.