Growth and remodeling of load-bearing biological soft tissues

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• 作者：C. J. Cyron ; J. D. Humphrey
• 关键词：Biomechanics ; Growth ; Remodeling ; Constrained mixture
• 刊名：Meccanica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：52
• 期：3
• 页码：645-664
• 全文大小：
• 刊物类别：Physics and Astronomy
• 刊物主题：Classical Mechanics; Civil Engineering; Automotive Engineering; Mechanical Engineering;
• 出版者：Springer Netherlands
• ISSN：1572-9648
• 卷排序：52

文摘

The past two decades reveal a growing role of continuum biomechanics in understanding homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly review the two primary theoretical approaches for describing mechano-regulated soft tissue growth and remodeling on the continuum level as well as hybrid approaches that attempt to combine the advantages of these two approaches while avoiding their disadvantages. We also discuss emerging concepts, including that of mechanobiological stability. Moreover, to motivate and put into context the different theoretical approaches, we briefly review findings from mechanobiology that show the importance of mass turnover and the prestressing of both extant and new extracellular matrix in most cases of growth and remodeling. For illustrative purposes, these concepts and findings are discussed, in large part, within the context of two load-bearing, collagen dominated soft tissues—tendons/ligaments and blood vessels. We conclude by emphasizing further examples, needs, and opportunities in this exciting field of modeling soft tissues.