Wound healing of dehiscence defects following different root conditioning modalities: an experimental study in dogs

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• 作者：Daniela Leal Zandim (1) (6)
  Fábio Renato Manzolli Leite (2)
  Vanessa Camila da Silva (3)
  Beatriz Maria Valério Lopes (4)
  Luiz Carlos Spolidorio (5)
  José Eduardo Cezar Sampaio (1)
  
• 关键词：Root surface conditioning ; Periodontal wound healing ; Regeneration ; Cementum ; Bone healing
• 刊名：Clinical Oral Investigations
• 出版年：2013
• 出版时间：July 2013
• 年：2013
• 卷：17
• 期：6
• 页码：1585-1593
• 全文大小：780KB
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• 作者单位：Daniela Leal Zandim (1) (6)
  Fábio Renato Manzolli Leite (2)
  Vanessa Camila da Silva (3)
  Beatriz Maria Valério Lopes (4)
  Luiz Carlos Spolidorio (5)
  José Eduardo Cezar Sampaio (1)
  
  1. Department of Diagnosis and Surgery, Araraquara Dental School, S?o Paulo State University (UNESP), Araraquara, SP, Brazil
  6. Disciplina de Periodontia, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, UNESP, Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil
  2. Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil
  3. Department of Periodontology and Surgery, School of Dentistry, Maranh?o Federal University (UFMA), S?o Luís, Maranh?o, Brazil
  4. Oral Biology Postgraduate Program, Universidade Sagrado Cora??o (USC), Bauru, SP, Brazil
  5. Department of Physiology and Pathology, Araraquara Dental School, S?o Paulo State University (UNESP), Araraquara, SP, Brazil
  
• ISSN：1436-3771

文摘

Objective The purpose of this study was to investigate the periodontal healing pattern of dehiscence-type defects following different chemical root conditioning modalities. Materials and methods Buccal osseous dehiscence defects were created on six teeth of seven dogs. After dental plaque accumulation, defects were treated with sterile saline solution (control group) or one chemical conditioning modality: citric acid (CA group), ethylenediaminetetraacetic acid (EDTA group), tetracycline (TTC group), citric acid-?tetracycline (CA-?TTC group), or tetracycline-?citric acid (TTC-?CA group). After 3?months of healing, clinical parameters were evaluated, and the animals were killed. Histological sections were processed, and a computer-assisted histometric analysis was used to evaluate the formation of new cementum, new bone, and epithelial apical migration. Results All treatments yielded significant improvements in terms of probing depth decrease and clinical attachment level gain compared to baseline values; however, without significant differences among the groups (p-gt;-.05; one-way ANOVA). The highest amount of new cementum was noted in the EDTA group (3.72?±-.83?mm, 77.6?%), while the lowest amount of new bone was observed in the TTC group (0.7?±-.94?mm, 14.3?%). However, no statistically significant differences could be observed among the groups regarding epithelial apical migration, new cementum, and alveolar bone formation (p-gt;-.05). Conclusion Chemical root surface conditioning did not promote any significant improvement in periodontal healing pattern of dehiscence-type defects in dogs. Clinical Relevance: Chemical root surface conditioning after surgical debridement did not promote positive or negative effects on periodontal healing pattern of dehiscence-type defects.