Age-associated brain regions in gliomas: a volumetric analysis

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• 作者：Yinyan Wang ; Shuai Liu ; Xing Fan ; Shaowu Li ; Renzhi Wang&#8230
• 关键词：Glioma ; Age ; Tumor location ; Voxel ; based mapping
• 刊名：Journal of Neuro-Oncology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：123
• 期：2
• 页码：299-306
• 全文大小：631 KB
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• 作者单位：Yinyan Wang (1) (2)
  Shuai Liu (3)
  Xing Fan (2)
  Shaowu Li (4)
  Renzhi Wang (3)
  Lei Wang (2) (5)
  Jun Ma (4)
  Tao Jiang (1) (2) (6)
  Wenbin Ma (3)
  
  1. Beijing Neurosurgical Institute, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China
  2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
  3. Departments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
  4. Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China
  5. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China
  6. Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, 100069, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Both age of patients and tumor location are associated with tumor origin, genetic characteristics, and prognosis. The objective of this study was to investigate the relationship between tumor location and age at diagnosis in a large cohort of patients with a primary diagnosis of glioma. We consecutively enrolled a cohort of 200 adults with glioblastoma and another cohort of 200 adults with diffuse low-grade gliomas. The magnetic resonance images of all tumors were manually segmented and then registered to a standard brain space. By using voxel-by-voxel regression analysis, specific brains regions associated with advanced age at tumor diagnosis were localized. In the low-grade gliomas cohort, the brain regions associated with advanced age at tumor diagnosis were mainly located in the right middle frontal region, while a region in the left temporal lobe, particularly at the subgranular zone, was associated with lower age at tumor diagnosis. In the glioblastoma cohort, the brain regions associated with advanced age at tumor diagnosis were mainly located in the temporal lobe, particularly at the posterior region of the subventricular zones. A region in the left inferior frontal region was associated with lower age at tumor diagnosis. Significant differences in the age of patients were found between tumors located in the identified regions and those located elsewhere in both cohorts. The current study demonstrated the correlation between tumor location and age at diagnosis, which implies differences in the origin of gliomas in young and older patients.