An improved genome assembly uncovers prolific tandem repeats in Atlantic cod

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• 作者：Ole K. Tørresen ; Bastiaan Star ; Sissel Jentoft ; William B. Reinar…
• 关键词：Assembly algorithms ; Assembly consolidation ; Dinucleotide repeats ; Gadus morhua ; Heterozygosity ; Indel polymorphism ; Long ; read sequencing technology ; Microsatellites ; PacBio ; Repetitive DNA
• 刊名：BMC Genomics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1266KB
• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164
• 卷排序：18

文摘

BackgroundThe first Atlantic cod (Gadus morhua) genome assembly published in 2011 was one of the early genome assemblies exclusively based on high-throughput 454 pyrosequencing. Since then, rapid advances in sequencing technologies have led to a multitude of assemblies generated for complex genomes, although many of these are of a fragmented nature with a significant fraction of bases in gaps. The development of long-read sequencing and improved software now enable the generation of more contiguous genome assemblies.