Optimal aspect ratio of endocytosed spherocylindrical nanoparticle

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• 作者：Ying-Bing Chen (2)
  Yan-Hui Liu (1) (2) (3)
  Yan Zeng (4)
  Wei Mao (2)
  Lin Hu (2)
  Zong-Liang Mao (2)
  Hou-Qiang Xu (1)
  
  2. Soft Condensed Matter Laboratory ; College of Science ; Guizhou University ; Guiyang ; 550025 ; China
  1. Key Laboratory of Animal Genetics ; Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education ; College of Animal Science ; Guizhou University ; Guiyang ; 550025 ; China
  3. State Key Laboratory of Theoretical Physics ; Institute of Theoretical Physics ; Chinese Academy of Sciences ; Beijing ; 100190 ; China
  4. College of Civil Engineering ; Guizhou University ; Guiyang ; 550025 ; China
  
• 关键词：cellular uptake ; depletion effects ; dimension of ligand ; receptor complex ; elasticity theory
• 刊名：Frontiers of Physics
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：10
• 期：1
• 页码：116-120
• 全文大小：335 KB
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• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Chinese Library of Science
  
• 出版者：Higher Education Press, co-published with Springer-Verlag GmbH
• ISSN：2095-0470

文摘

Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.