Increased risk of large-for-gestational age birthweight in singleton siblings conceived with in vitro fertilization in frozen versus fresh cycles

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• 作者：Barbara Luke ; Morton B. Brown ; Ethan Wantman…
• 关键词：Assisted reproductive technology ; Siblings ; Fresh and thawed cycles ; Birth outcomes
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：2
• 页码：191-200
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Gynecology; Reproductive Medicine; Human Genetics;
• 出版者：Springer US
• ISSN：1573-7330
• 卷排序：34

文摘

BackgroundChildren born from fresh in vitro fertilization (IVF) cycles are at greater risk of being born smaller and earlier, even when limited to singletons; those born from frozen cycles have an increased risk of large-for-gestational age (LGA) birthweight (z-score ≥1.28). This analysis sought to overcome limitations in other studies by using pairs of siblings, and accounting for prior cycle outcomes, maternal characteristics, and embryo state and stage.