Current status in cancer cell reprogramming and its clinical implications
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- 作者：Kenan Izgi ; Halit Canatan…
- 关键词：Reprogramming ; Cancer ; Induced pluripotent stem cells ; Pluripotency ; Epigenetics
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：143
- 期：3
- 页码：371-383
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
PurposeThe technology of reprogramming a terminally differentiated cell to an embryonic-like state uncovered the possibility of reprogramming a malignant cell back to a more manageable stem cell-like state. Since the current cancer models suffer from reflecting heterogeneous tumour structure and limited to express the late-stage markers, the induced pluripotent stem cell (iPSC) technology could provide an alternative model to recapitulate the early stages of cancer. Generation of iPSCs from cancer cells could offer a tool for understanding the mechanisms of tumour initiation–progression in vitro, a platform for studying tumour heterogeneity and origin of cancer stem cells and a source for cancer type-specific drug discovery studies.